• Vaccine Ontology ID: VO_0004548
• Type: DNA vaccine
• Status: Research
• prM from Dengue virus 1 gene engineering:
  • Type: DNA vaccine construction
  • Detailed Gene Information: Click Here.
• E from Dengue virus 1 gene engineering:
  • Type: DNA vaccine construction
  • Detailed Gene Information: Click Here.
• Vector: D1ME-DNA (Chen et al., 2007)
• Immunization Route: Intramuscular injection (i.m.)

Baboon Response

• Vaccination Protocol: Monkeys were divided into groups DDD, VVV, DDV, and control and immunized with D1ME-DNA or D1ME-VRP as shown in the study design. D1ME-DNA was administered intramuscularly, with 0.5 ml given in each of the two upper arms. D1ME-VRP was delivered intramuscularly, as well (Chen et al., 2007).
• Vaccine Immune Response Type: VO_0003057
• Immune Response: After the third dose of vaccine, all animals in the DDD group, VVV group, and DDV group had developed neutralizing antibodies. The dengue virus 1-specific IgG response to all vaccination regimens was predominantly of the IgG1 type, with smaller amounts of IgG2 and no measurable amounts of IgG4 (Chen et al., 2007).
• Challenge Protocol: Twenty weeks after the final immunization, animals were challenged by subcutaneous injection of 10^5 PFU of live dengue virus 1 (Western Pacific 74 strain) in a 0.5-ml volume (Chen et al., 2007).
• Efficacy: All vaccination regimens showed significant protection from viremia compared to that of the unvaccinated control group (Chen et al., 2007).