|
|
Vaccine Detail
|
Human Respiratory Syncytial Virus M2-2 mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002978
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: African green monkey
- M2-2
gene engineering:
- Type: Gene mutation
- Description: This M2-2 is from Human Respiratory Syncytial Virus (Jin et al., 2003).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
|
| Host Response |
|
Monkey Response
- Persistence: An M2-2 mutant is attenuated in African green monkeys (Jin et al., 2003).
- Efficacy: An M2-2 mutant induces significant protection in African green monkeys from challenge with wild type HRSV (Jin et al., 2003).
|
| References |
Jin et al., 2003: Jin H, Cheng X, Traina-Dorge VL, Park HJ, Zhou H, Soike K, Kemble G. Evaluation of recombinant respiratory syncytial virus gene deletion mutants in African green monkeys for their potential as live attenuated vaccine candidates. Vaccine. 2003; 21(25-26); 3647-3652. [PubMed: 12922094].
|
|
