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Vaccine Detail
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B. pseudomallei Subunit LolC Protein Vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0011436
- Type: Subunit vaccine
- Status: Research
- LolC/E
gene engineering:
- Type: Recombinant protein preparation
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Mouse Response
- Host Strain: BALB/c
- Vaccination Protocol: Female 5- to 6-week-old BALB/c mice were immunized with the purified recombinant LolC protein given with adjuvant (Harland et al., 2007).
- Challenge Protocol: Mice immunized with the LolC protein or appropriate controls were challenged with B. pseudomallei K96243 on day 70 (Harland et al., 2007).
- Efficacy: The recombinant LolC protein afforded significant protection against the B. pseudomallei challenge (Harland et al., 2007).
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| References |
Harland et al., 2007: Harland DN, Chu K, Haque A, Nelson M, Walker NJ, Sarkar-Tyson M, Atkins TP, Moore B, Brown KA, Bancroft G, Titball RW, Atkins HS. Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis. Infection and immunity. 2007; 75(8); 4173-4180. [PubMed: 17517877].
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