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Vaccine Detail
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rSPV-MRP (Streptococcus suis) |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004635
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Mouse
- Vector: (Huang et al., 2012)
- Preparation: A swinepox virus (SPV) was used as a vector to express truncated muramidase-released protein (MRP) of S. suis type 2 (SS2), designated rSPV-MRP (Huang et al., 2012).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccination Protocol: Mice were immunized intramuscularly with rSPV-MRP, SS2 inactive vaccine (positive control), wild-type SPV (negative control) and PBS (blank control) (Huang et al., 2012).
- Vaccine Immune Response Type: VO_0003057
- Challenge Protocol: All CD1 mice were challenged with a lethal dose or a sublethal dose of SS2 highly virulent strain ZY05719 (Huang et al., 2012).
- Efficacy: SS2 inactive vaccine protected all mice, immunization with rSPV-MRP resulted in 60% survival and protected mice against a lethal dose of the highly virulent SS2 strain, compared with the negative control (Huang et al., 2012).
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| References |
Huang et al., 2012: Huang D, Zhu H, Lin H, Xu J, Lu C. First insights into the protective effects of a recombinant swinepox virus expressing truncated MRP of Streptococcus suis type 2 in mice. Berliner und Munchener tierarztliche Wochenschrift. 2012; 125(3-4); 144-152. [PubMed: 22515033].
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