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Vaccine Detail
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Chinese S. japonicum DNA vaccine SjCTPI-Hsp70 |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004459
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Water buffalo
- TPI
gene engineering:
- Type: DNA vaccine construction
- Description: This DNA vaccine expressed triose-phosphate isomerase (SjCTPI) fused to bovine heat shock protein 70 (Da'dara et al., 2008).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Water buffalo Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: This vaccine produced a 51.2% reduction in worm burden, 61.5% liver egg reduction, 52.1% fecal egg reduction and 52.1% reduction in fecal miracidia (Da'dara et al., 2008).
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| References |
Da'dara et al., 2008: Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine. 2008; 26(29-30); 3617-3625. [PubMed: 18524429].
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