• Type: DNA vaccine
• Status: Clinical trial
• Host Species for Licensed Use: Human
• Antigen: S protein (Martin et al., 2008)
• Immunization Route: Intramuscular injection (i.m.)
• Description: A single-plasmid DNA vaccine encoding the Spike (S) glycoprotein. (Martin et al., 2008)

Human Response

• Vaccination Protocol: Injections on study days 0, 28, and 56 at a 4 mg dose in the lateral deltoid muscle (Martin et al., 2008)
• Immune Response: S-specific antibody, neutralizing antibodies present. S-specific CD4+ T cell response was detected in all patients, where on 20% had S-specific CD8+ T cell responses. (Martin et al., 2008)
• Side Effects: Chills, fever, headache, injection site pain, malaise, myalgia, redness, swelling, tenderness (Martin et al., 2008)