• Vaccine Ontology ID: VO_0009041
• Type: Subunit vaccine
• Status: Research
• Host Species as Laboratory Animal Model: human lymphocytes
• Preparation: Phenol-extracted fraction (PI); another phenol-extracted and peptidoglycan containing fraction (4A) was also used in vitro. (Bascoul et al, 1976)
• Description: The PI fraction, a phenol-extracted fraction from Brucella melitensis, has been used for years in the laboratory for vaccination of laboratory and agricultural workers considered at risk. Immune response: Correlation observed between lymphocyte stimulation index, humoral antibodies to Brucella, and cutaneous response to PI in vaccinated subjects. (Bascoul et al, 1976)

Human Response

• Immune Response: Correlation observed between lymphocyte stimulation index, humoral antibodies to Brucella, and cutaneous response to PI in vaccinated subjects. (Bascoul et al, 1976)
• Description: In vitro lymphocyte transformation test using human lymphocytes; correlation studies of stimulation index with humoral antibodies and cutaneous response in vaccinated subjects, brucellosis patients, and normal controls. (Bascoul et al, 1976)