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Vaccine Detail

Equid herpesvirus TK mutant vaccine

Vaccine Information

Product Name: PR1
Vaccine Ontology ID: VO_0002957
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse, horse
TK gene engineering:
- Type: Gene mutation
- Description: This TK mutant is from Equid herpesvirus 1 (Slater et al., 1993).
- Detailed Gene Information: Click Here.
Immunization Route: intranasal immunization

Host Response

Mouse Response

Persistence: A TK mutant is attenuated in mice (Slater et al., 1993).
Efficacy: A TK mutant induces significant protection from challenge with wild type EHV (Slater et al., 1993).

Horse Response

Persistence: A TK mutant is attenuated in foals (Slater et al., 1993).
Efficacy: A TK mutant provides partial protection in foals from challenge with wild type EHV (Slater et al., 1993).

References

Slater et al., 1993: Slater JD, Gibson JS, Field HJ. Pathogenicity of a thymidine kinase-deficient mutant of equine herpesvirus 1 in mice and specific pathogen-free foals. The Journal of general virology. 1993; 74 ( Pt 5); 819-828. [PubMed: 8388018].