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Vaccine Detail
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BoHV-4-A-gD(cp)gD(106)ΔTK |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004685
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Preparation: The bovine herpesvirus 4 (BoHV-4) based vector derived from an apathogenic isolate of BoHV-4 was used to express the immunodominant CpHV-1 glycoprotein D (BoHV-4-A-gD(cp)gD(106)ΔTK) (Donofrio et al., 2013).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Goat Response
- Vaccination Protocol: Goats were vaccinated with BoHV-4-A-gD(cp)gD(106)ΔTK (Donofrio et al., 2013).
- Vaccine Immune Response Type: VO_0003057
- Immune Response: No clinical signs were evident but a good titer of serum neutralizing antibodies was produced in all inoculated animals (Donofrio et al., 2013).
- Challenge Protocol: A challenge experiment was performed in a new group of animals using a highly pathogenic dose of CpHV-1 (Donofrio et al., 2013).
- Efficacy: All the vaccinated goats with BoHV-4-A-gD(cp)gD(106)ΔTK were protected toward CpHV-1 induced genital disease respect to the unvaccinated control goat who showed typical vaginal lesions with a high grade of clinical score as well as a long lasting viral shedding (Donofrio et al., 2013).
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| References |
Donofrio et al., 2013: Donofrio G, Franceschi V, Lovero A, Capocefalo A, Camero M, Losurdo M, Cavirani S, Marinaro M, Grandolfo E, Buonavoglia C, Tempesta M. Clinical protection of goats against CpHV-1 induced genital disease with a BoHV-4-based vector expressing CpHV-1 gD. PloS one. 2013; 8(1); e52758. [PubMed: 23300989].
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