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apxIIIB

Gene Name apxIIIB
Sequence Strain (Species/Organism) Actinobacillus pleuropneumoniae serovar 2
NCBI Nucleotide GI 470686
Other Database IDs CDD:30270
CDD:162558
CDD:186074
CDD:73011
Taxonomy ID 34063
Gene Strand (Orientation) ?
Protein Name RTX toxin
Protein Note A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine'...; cd02417
DNA Sequence 
>gb|L12145.1|ACNNON:3943-6078 Actinobacillus pleuropneumoniae (serotype 2) RTX toxin III (apxIII CABD) genes, complete cds
ATGGAGTCACAAATGCCTTTTAACGAAAAAATAGATTACGGATTACATGCATTGGTAATTCTCGCGCAAT
ATCACAATGTTGCCGTAAACCCTGAAGAGGTAAAACATAAATTTGATCTTGATGGCAAAGGATTGGATCT
TGTTGCTTGGTTATTAGCAGCAAAATCATTAGAATTAAAAGTCAAACGAGTAAAAAAGAGTATTGAGCGT
TTACCATTTATTCATCTTCCTGCTTTAATCTGGCGAGATGATGGTCAACACGTTATTTTGATGAAAATTG
ACACCCAAACTAACCGTTACCTTATTTTTGACTTAGAAGAACGAAACCCTAAAGTACTAAGTGCGGCTGA
ATTTCACGAAATTTTTCAAGGTGGTATGATTCTTATTACTTCACGAGCTTCTATTATGGGGCAATTGGCG
AAGTTTGATTTCACTTGGTTTATCCCCGCAGTAATTAAATACCGTAAAATTTTTGTAGAAACTATTATTG
TTTCTATTTTTTTGCAGCTTTTTGCACTAATTACTCCCTTATTTTTCCAAGTTGTGATGGATAAAGTTCT
TGTCCATCGTGGATTTTCTACACTTAATGTTATCACGGTTGCATTATCTGTAGTGGTTATCTTTGAAATT
GTATTAAGCGGTCTACGGACTTATATATTTTCCCATAGCACTAGCCGAATTGATGTAGAACTTGGTGCAA
AATTATTTCGTCACTTGTTAGCGTTACCTATTTCTTATTTCGAAAATAGACGTGTAGGTGACACAGTTGC
TCGAGTACGAGAATTGGATCAAATACGCAATTTTTTAACAGGTCAGGCACTTACCTCTGTATTAGATCTC
TTATTCTCTTTTATTTTCTTTGCAGTGATGTGGTATTACAGCCCAAAACTAACTATTGTGATTTTACTTT
CATTACCTTGTTATATCGCATGGTCAATATTTATTAGCCCAATATTACGTCGTCGTCTAGATGAAAAATT
TGCTCGTAATGCTGATAATCAATCTTTTTTAGTTGAATCTGTTTCTGCAATAGACACGATCAAGGCTCTT
GCTGTAACACCTCAAATGACAAATATTTGGGATAAACAGTTAGCAAGTTATGTATCAGCAGATTTTAGAG
TGACAGTATTGGCAACTATTGGACAGCAAGGTGTACAACTTATCCAAAAAACAGTAATGATAATTAATTT
ATGGTTAGGTGCACATTTAGTAATTTCAGGGGATCTTAGCATTGGACAATTAATTACTTTTAATATGCTT
TCAGGACAAGTTATTGCACCTGTAGTTCGTTTAGCACAATTGTGGCAAGACTTTCAACAAGTAGGAATTT
CTATTACACGATTGGGAGATGTCTTAAATTCACCTACAGAAAATTATCAAGGTAAGCTTTCACTACCAGA
AATCTTTGGGGATATCGCATTTAAACATATTCGCTTTCGCTATAAGCCCGATGCTCCAATCATTTTAGAT
GATGTAAATTTATCGGTTAAACAGGGGGAAGTTATTGGGATAGTAGGACGTTCAGGTTCAGGTAAAAGTA
CTCTCACTAAATTATTACAACGTTTTTATATTCCGGAAAATGGCCAAGTATTGATTGATGGTCACGATCT
TGCGCTTGCTGATCCTAATTGGTTACGTCGTCAAATTGGTGTTGTTTTACAAGATAATGTGTTATTAAAC
CGTAGTATTCGCGATAATATCGCACTCACTGATCCAAGCATGTCTATGGAACGTGTTATCTATGCGGCAA
AATTAGCAGGGGCACATGATTTTATTTCTGAATTACGTGAAGGTTACAATACTATTGTAGGAGAGCTTGG
TGCAGGCTTATCTGGTGGACAACGTCAACGGATTGCTATTGCACGAGCTTTAGTCAATAACCCTAGGATT
TTGATTTTTGATGAGGCGACAAGTGCATTAGATTATGAATCTGAACATATCATTATGCAAAATATGCAAA
AAATCTGCCATGGACGGACAGTAATCATTATTGCCCACCGTCTTTCTACAGTAAAAAATGCGGATCGCAT
TATTGTTATGGAAAAGGGACATATTGTAGAGCAAGGTAAACATAACCAATTACTGGAAAATGAAAATGGA
CTCTATTATTACCTCAACCAACTACAATCAAATTAA
Molecule Role Virmugen
Molecule Role Annotation An apxIIIB mutant, in combination with an apxIIID mutation, is highly attenuated in pigs and induces significant protection from challenge with wild type A. pleuropneumoniae. The mutant also was slightly attenuated in mice and induced protection in mice against challenge from the parent strain (Park et al., 2009).
Related Vaccines(s) Actinobacillus pleuropneumoniae apxIIIB and apxIIID double mutant vaccine
References