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apxIA

Gene Name apxIA
Sequence Strain (Species/Organism) Actinobacillus pleuropneumoniae L20
NCBI Gene ID 4850247
NCBI Protein GI 126208908
Locus Tag APL_1444
Genbank Accession CP000569
Protein Accession YP_001054133
Taxonomy ID 416269
Gene Starting Position 1652926
Gene Ending Position 1655994
Gene Strand (Orientation) -
Protein Name RTX-I toxin determinant A
Protein pI 5.34
Protein Weight 104673.05
Protein Length 1022
Protein Note pubmed:8359891
DNA Sequence 
>gi|126207488:1652926-1655994 Actinobacillus pleuropneumoniae L20, complete genome
CTTAAGCAGATTGTGTTAAATAATTACTGAAAGCATTCGGTATGCTATTCGGTGAATTGCTGTAAGCTAA
TGGACCGCCTGCTCCCACTAAAACTTGTCCGTGTTCACCGGTAAGTGCACCAGTAGATGAAATGATTTGT
TCAATATCTTTTCTGAGTTGAGGAAGTGCATTATATCCTTCTCCATAATACAATTTTTCTTCTAACCCAT
TAAAGTAATTGATACCTCTTCCAGGAGCTGTCAGTTCAGTCAGATATTGGCTTAAAACATAAGCTCCATC
TTTATCAACGATTTTTTCAATTTTATTATTTTGTCCTTCTTTACCTTCCTTGAACCAATCTTTAATCGTG
AGCGCATTCCCATTGTAATCTTCATGGTAATACAGTGTTCCTCCGATTCTTTTATTCACAAGAAGATCAT
CACCGATTCTGATAAATCCTACATCTTTAAAACTAAGATCCGATAACAATAACGTATCATCATCACCGCC
TTTCTCAATAATGATATGACGACCGTACTCCTTACTGTAGCGATAAATATCCTTACCTAAACCACCGTAG
ATTTTGTCATTGCCTACACCACCGTCAAATAAGTTAGTACCATCGCTGCCATACAGAATGTCATTACCCG
CACCACCTAATAATACGTTGTATTGACCCTCAAAGACCTGCAACTCATCGTCACCATCACCGCCATTAAG
GAAATTATTACCTTTTCCGCCGATTAATCGGTCGTTTCCGTTACCACCAACAAGATGGTCGTTACCGTCA
CCGCCATGGATTACATCATTACCGTCGTCTCCGTATAAGATATCGTGGCCGTCATTACCGTAGATTTCAT
CATCGCCTTTCGCACCATGGAAAATATCGGTAAAGCGACTACCAAAGAATTTGTCTTTACGATTACTACC
GATAATTTCTTCAACAGAATGTAATTCATCTTTAGCTCTGATACCGTTCCCAAGTTCGAATGGGCTTAAC
TCATAATCACGATATTCTAATTTTTCACTGCGTTTTCCAACTGAAATATCCTGAGTTTTAACCACTTCTT
TTAAAACTTTTACATCAGCTTTAAGTTCTTTAGTGACAATATATTCACCGGCTTTCTGTGCACTTTGTCC
GTCAAATGTTAAGTAACCTGTATCGGTTTTATCGTAATATGCTACATCATGTCCGTTACCCGCATATACG
ATAGATGAACCGGATGAAAGATATATACGATCATTTTTCTCACCCAAATGAGATTCAATGGTCACTTGAC
GTTTTTCACCTTTTTTATCTATCGCTAATTGGATAAGATTCGTATAGTCATAAATCGCATTATGTGACTG
CACACCGGTTACCACCCATTTTTCTTTACCTTTAACGAATAATTCGGTCATATATTCGTATTTACCGGTT
TGCTTACGCTCACGAATCTCTTCACCTGCGGTAAAAACCGGTGTAATAAATTTCAATAAAGTGGTTTTGT
TAATTGAAGAAAGGTCGATTTTGCCTTCAAGCGGATCAAACACTTTTTTATCAAAACGATCCGGATCTTT
CTCTAACAATTTTCCTTCTTCAAAGAAATCGACATAAGCCTTACCGCTTTTCGCATCCGCACCTTTACGC
GTGATACCGGCAAGTTCCCCGATATTGACATCCCAACGTTGTTGCGTAATAGCAACGACACGCTCTACCG
AATACTCTTTATTGTATTGTGATAACAATTCAAAGGTATCTTCTAAGAATGCGGAATGGCGGGCGTCATA
ACCGTTTTCAAAATAGTTTTTACCGTGTTTTTTCTCCCATTCGTCAATCTTATTCGCTAATTTCGTTGCA
ACTCGTTCGAAGATTGCCTGTTTAGAAGCATCTAAAATACCTGAAATAATACCGGTGATTGCACTAACTA
AAGCTGCTACCGGCGCACCGACTAATGAGCCGGTTGCAGCAGCCCCAACACCTGCGGAAGCCGCACTTAA
CACACTGTTAATCGTGGTTAATGCCGCTTCAATCGCACCGGTTTCACGGTAGAATGAAGCTAATAAACTA
TCACCTTCATAACCGAACTTTTTAAAGCGCTCCGAATATTGTTCAAGCTGTTTCGCACGTTCAAACTTAT
CCGCAACATTTAAGAACGAAAGCGGGCTAATCGCTAATGCTACGACCGAACCGATTAAACCACCGGTTGC
CGCAGTTGTGGATAAGCCTGCCGCCACACGTTGCGCAATAATATATTGAGAAACCGCTTTACCGATATTG
CCTAAGATTTTAGTTGAGATTTCAATACCTGCCGCCGCTTTTGTACCTGCATCGGCATCTTTATTACTTA
AAATGAATGAAGCCGAAACAACAGATAAGATACCTGATACGGCATCAAACCCAGGTCCTGCAAGGCTTAA
ATCTGGAAGGTTATTTAACTTACTTGCTAAACCGCTTAAGCGAGTGTTAGATAAGGCATTGCCCAATTTA
CCTAATTGTTCGGCAAACGCATCCACCGTACCCGTTGCACTTGCAATGTTATCCACTAACTGAGCGGCTA
GATCCACACCCGCTTTAGCTAATTCCGAACCACTGACGTCCTCACCGTTTCTACGGCGACGAAGCAGGCT
ATCAAGATCCATACCCGCAATAGCCGTACCTAAGAAACTTTGTAAGGCTGAAAGTGCCGTTTGCGTTTTA
TTTAAACGTTGTCCTAATGCTTCCGATGAACCGCCGAGCGATTTACTTAATTTTTGGTTCTTATTCAGTA
ACTTATCAAACTGAGGTGCAAATAATGCGATGCCTCGTTCCGAGAAACCTAATAGTTTTTCCGTTGTACC
GAATAATTCTTTCGCTAGTGCGGTACCGTTTTTTTCCGAGCGATGTACTTCGATCCCTAAAGCCTCCGCC
GCTTTCACTAAATCATTAAGACTTGAGCCGGTACTAGCTTGATAATCTTTCGGAATATATAAAATTAATT
TCTGCCCTGCTTGCTTCACCTGTCCCAAACCATTTTTTAATGCGCCGGCACCTGATTTAGCTGCACTTTT
TGTATGTTGATTAAGTGAATCAATCAATCCTTTGACTCTATCGAGCTGAGAGTTAGCCA
Protein Sequence 
>gi|126208908|ref|YP_001054133.1| RTX-I toxin determinant A [Actinobacillus pleuropneumoniae L20]
MANSQLDRVKGLIDSLNQHTKSAAKSGAGALKNGLGQVKQAGQKLILYIPKDYQASTGSSLNDLVKAAEA
LGIEVHRSEKNGTALAKELFGTTEKLLGFSERGIALFAPQFDKLLNKNQKLSKSLGGSSEALGQRLNKTQ
TALSALQSFLGTAIAGMDLDSLLRRRRNGEDVSGSELAKAGVDLAAQLVDNIASATGTVDAFAEQLGKLG
NALSNTRLSGLASKLNNLPDLSLAGPGFDAVSGILSVVSASFILSNKDADAGTKAAAGIEISTKILGNIG
KAVSQYIIAQRVAAGLSTTAATGGLIGSVVALAISPLSFLNVADKFERAKQLEQYSERFKKFGYEGDSLL
ASFYRETGAIEAALTTINSVLSAASAGVGAAATGSLVGAPVAALVSAITGIISGILDASKQAIFERVATK
LANKIDEWEKKHGKNYFENGYDARHSAFLEDTFELLSQYNKEYSVERVVAITQQRWDVNIGELAGITRKG
ADAKSGKAYVDFFEEGKLLEKDPDRFDKKVFDPLEGKIDLSSINKTTLLKFITPVFTAGEEIRERKQTGK
YEYMTELFVKGKEKWVVTGVQSHNAIYDYTNLIQLAIDKKGEKRQVTIESHLGEKNDRIYLSSGSSIVYA
GNGHDVAYYDKTDTGYLTFDGQSAQKAGEYIVTKELKADVKVLKEVVKTQDISVGKRSEKLEYRDYELSP
FELGNGIRAKDELHSVEEIIGSNRKDKFFGSRFTDIFHGAKGDDEIYGNDGHDILYGDDGNDVIHGGDGN
DHLVGGNGNDRLIGGKGNNFLNGGDGDDELQVFEGQYNVLLGGAGNDILYGSDGTNLFDGGVGNDKIYGG
LGKDIYRYSKEYGRHIIIEKGGDDDTLLLSDLSFKDVGFIRIGDDLLVNKRIGGTLYYHEDYNGNALTIK
DWFKEGKEGQNNKIEKIVDKDGAYVLSQYLTELTAPGRGINYFNGLEEKLYYGEGYNALPQLRKDIEQII
SSTGALTGEHGQVLVGAGGPLAYSNSPNSIPNAFSNYLTQSA
Molecule Role Virmugen
Molecule Role Annotation The mutant strain, with deletion of apxIA gene, obtained in this study offered a level of cross-serovar protection against A. pleuropneumoniae infection in mice and pigs (Xu et al., 2006).
Related Vaccines(s) Actinobacillus pleuropneumoniae apxIA mutant vaccine
References