VIOLIN: Vaccine Investigation and Online Information Network

proC
Gene Name	proC
Sequence Strain (Species/Organism)	Mycobacterium tuberculosis H37Rv
NCBI Gene ID	887256
NCBI Protein GI	15607641
Locus Tag	Rv0500
Genbank Accession	BX842573
Protein Accession	NP_215014
Taxonomy ID	83332
Gene Starting Position	590082
Gene Ending Position	590969
Gene Strand (Orientation)	?
Protein Name	pyrroline-5-carboxylate reductase
Protein pI	4.42
Protein Weight	26600.99
Protein Length	295
Protein Note	catalyzes the formation of L-proline from pyrroline-5-carboxylate
DNA Sequence	>gi\|57116681:590082-590969 Mycobacterium tuberculosis H37Rv, complete genome GATGCTTTTCGGCATGGCAAGGATCGCGATTATCGGCGGCGGCAGCATCGGTGAGGCATTGCTGTCGGGT CTGCTGCGGGCGGGCCGGCAGGTCAAAGACCTGGTAGTGGCCGAGCGGATGCCCGATCGCGCCAACTACC TGGCGCAGACCTATTCGGTGTTGGTGACGTCGGCGGCCGACGCGGTGGAGAACGCGACGTTCGTCGTCGT CGCGGTCAAACCAGCCGACGTCGAGCCGGTGATCGCGGATCTGGCGAACGCGACTGCGGCGGCCGAAAAC GACAGTGCTGAGCAGGTGTTCGTCACCGTGGTAGCGGGCATCACGATCGCGTATTTCGAATCCAAGCTAC CGGCTGGGACGCCAGTGGTGCGTGCGATGCCGAACGCGGCGGCATTGGTGGGAGCGGGGGTTACAGCGCT GGCCAAAGGCCGCTTTGTCACCCCGCAACAGCTTGAGGAGGTCTCGGCCTTGTTCGACGCGGTCGGCGGC GTGCTGACCGTTCCGGAATCGCAGTTGGACGCGGTGACCGCGGTGTCCGGCTCGGGTCCGGCCTATTTCT TTCTGCTGGTCGAGGCCCTGGTGGATGCCGGAGTCGGGGTGGGCTTGAGCCGTCAGGTGGCCACCGATCT CGCCGCGCAGACAATGGCTGGCTCAGCGGCGATGCTGCTGGAGCGGATGGAGCAAGACCAGGGTGGCGCC AATGGCGAGCTGATGGGGCTGCGCGTGGACCTTACCGCATCACGGCTGCGCGCCGCGGTTACCTCGCCGG GCGGTACGACCGCCGCTGCGCTGCGGGAACTCGAACGCGGCGGGTTTCGGATGGCTGTCGACGCGGCGGT TCAAGCCGCCAAAAGCCGCTCTGAGCAGCTCAGAATTACACCGGAATG
Protein Sequence	>gi\|15607641\|ref\|NP_215014.1\| pyrroline-5-carboxylate reductase [Mycobacterium tuberculosis H37Rv] MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVV AVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTAL AKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDL AAQTMAGSAAMLLERMEQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAV QAAKSRSEQLRITPE
Molecule Role	Virmugen
Molecule Role Annotation	A proC mutant is highly attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis that is equal to the protection induced by the current vaccine BCG (Smith et al., 2001).
Related Vaccines(s)	Mycobacterium tuberculosis proC mutant vaccine
References

proC