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Tarp
Gene Name	Tarp
Sequence Strain (Species/Organism)	Chlamydia muridarum str. Nigg
NCBI Gene ID	1245826
NCBI Protein GI	497916366
Locus Tag	TC_RS02355
Genbank Accession	AE002160
Protein Accession	WP_010230522
Taxonomy ID	243161
Gene Starting Position	571045
Gene Ending Position	572607
Gene Strand (Orientation)	+
Protein Name	peptide ABC transporter substrate-binding protein
Protein pI	9.01
Protein Weight	56833.03
Protein Length	520
Protein Note	similar to GB:D00760, SP:P25787, and PID:220024; identified by sequence similarity; putative
DNA Sequence	>NC_002620.2:571045-572607 Chlamydia muridarum Nigg, complete genome CATGCGCAAGGTATCAGTGGGAATCTGCTTGCTTATCGCATTAGCAACAGCAATTACCGGCTGCTCCAAA TCCTCCTCAAACAAATCAAATCACTCCTCCTCTAATCAAAGCGTATCTGTGAGCATGAAGGACGATCCTC GCACGTTTGACCCTCGAGAGGTTAGGCTTCTTTCGGATATTAATTTGATTCACCATCTTTATGAGGGACT GGTTCAAGAGACTCCTTCCGGAGAGGTTTTCCCTGCATTAGCAGAAAGTTTCTTCCTATCTGAAGATAAG AAAACCTACACTTTCCACCTAAAAAAAGCACTCTGGAGTAATGGAGACCTGATTACTGCTCATGATTTTG TACGTTCTTGGAACGATGTTTTGCAAAATCGCATTGCAAGTATCTACTCTTTCGCTTTTTTACCCATTGA TTTAAGTAAAGATTGTGGATTCTTCGCTAAGGACAATCATACACTTGTTATCAATTTGCATACCCCTACT CCACACTTTCTGAAATTACTTACCCTTCCAGTATTTTATCCTGTGCACCCCGAACATCAAATTCGGAATG AAGCAAAAGCTCTTCCAATATCTACAGGGGCTTTTTGTTTAAAAGAGAAAAAAGATCGGCGGTGGCTTAA ATTAGAAAAAAATCCCTATTATTATAACAAAGAGCAAGTTGCGATCCAGGAAATCCACATACATGTGATT CCTGATCAGCAGACCGCTTCTGCTTTGTTCAAACAAGGAAAATTGGATTGGCAAGGACTTCCTTGGGGAC ACAGCATTCCCCAAGAAGCTTTAGCAACAGCAAATAAACGTCGTACTCCTCAATCATTTGATATATCTGG CACCTCGTGGCTCACGTTCAACACATCAAAAGTACCCTTCAGCCATCCCAAGTTGCGACAAGCTTTAAGC CTTGTTCTAAATAAGGAAGCCTTAGCCTCTCCAACCTTTGTTAAGCCCGCTAAACACCTACTTCCTACAC ACCTGCACACTTATCCAGAGCAACCTACTTACAAACAACAAGAAGCCGTCATTTTAGCCAAAACTCTGTT ACAAGAAGCATTAACAGATCTTAATATGACTATAAAAGATCTTGAAAAATGCCCTTTGATTTTTTCAGCG ACATCTAGCGTCAACTCACAAATGGCCCAAATGATGCGCGATCAATGGCGAAGAATTTTAGGAATAACAT TCCCTATTTGCGGGAAAGAGTATGCTTTATTACAAAATGATTTGACCACCAACACTTTTTTTATGTCCAT AAACGGTTGGTTTGCAGACTTTTCCGATCCTTTAGCCTTCTTGTCTGTTTTTTCTTCTAAGGGAATCAAA CCTTATGCCTTACAAGACCCTCTGTTTGACCAGCTTATTCTCTCTATAGAAACGGAAAAAGATCCTCGAA AGCGTATTTCTCTGATTTCCGAAGCTTCTCTATACCTAGAAAAACAAAATATCATAGAACCGCTCTATCA CGATGTTTTTCACTATGCCGCAAATAATAAACTTTCTTTTGTTAGATTACATCCCTCAGGTCTTGTCGAT ATGCGGTATGCAAAAAACTCTTG
Protein Sequence	>WP_010230522.1 peptide ABC transporter substrate-binding protein [Chlamydia muridarum] MRKVSVGICLLIALATAITGCSKSSSNKSNHSSSNQSVSVSMKDDPRTFDPREVRLLSDINLIHHLYEGL VQETPSGEVFPALAESFFLSEDKKTYTFHLKKALWSNGDLITAHDFVRSWNDVLQNRIASIYSFAFLPID LSKDCGFFAKDNHTLVINLHTPTPHFLKLLTLPVFYPVHPEHQIRNEAKALPISTGAFCLKEKKDRRWLK LEKNPYYYNKEQVAIQEIHIHVIPDQQTASALFKQGKLDWQGLPWGHSIPQEALATANKRRTPQSFDISG TSWLTFNTSKVPFSHPKLRQALSLVLNKEALASPTFVKPAKHLLPTHLHTYPEQPTYKQQEAVILAKTLL QEALTDLNMTIKDLEKCPLIFSATSSVNSQMAQMMRDQWRRILGITFPICGKEYALLQNDLTTNTFFMSI NGWFADFSDPLAFLSVFSSKGIKPYALQDPLFDQLILSIETEKDPRKRISLISEASLYLEKQNIIEPLYH DVFHYAANNKLSFVRLHPSGLVDMRYAKNS
Molecule Role	Protective antigen
Molecule Role Annotation	Immunization of mice with Tarp induced Th1-dominant immunity that significantly reduced the shedding of live organisms from the lower genital tract and attenuated inflammatory pathologies in the fallopian tube tissues. Tarp, an immunodominant antigen identified by human antisera, can induce protective immunity against chlamydial infection and pathology in mice (Wang et al., 2009).
Related Vaccines(s)	C. muridarum Tarp subunit vaccine
References

Tarp