VIOLIN: Vaccine Investigation and Online Information Network

TmpB
Gene Name	TmpB
Sequence Strain (Species/Organism)	Treponema pallidum subsp. pallidum str. Nichols
VO ID	VO_0012400
NCBI Gene ID	2611387
NCBI Protein GI	499184674
Locus Tag	TP_RS03880
Genbank Accession	AE000520
Protein Accession	WP_010882214
Taxonomy ID	243276
Gene Starting Position	834955
Gene Ending Position	835932
Gene Strand (Orientation)	+
Protein Name	treponemal membrane protein B
Protein pI	9.18
Protein Weight	35471.38
Protein Length	325
Protein Note	similar to GB:M58562 SP:P19649 PID:155065 percent identity: 100.00; identified by sequence similarity; putative
DNA Sequence	>NC_000919.1:834955-835932 Treponema pallidum subsp. pallidum str. Nichols complete genome GATGAAGACACGTAATTTCTCGCTCGTATCCGCGTTGTACGTACTGCTGGGTGTTCCTCTGTTTGTGTCT GCCGCTTCCTACGACGACAATGAATTTTCTCGCAAGAGTCGTGCGTACTCGGAGCTTGCAGAGAAGACAT ACGATGCGGGAGAGTATGACGTCTCTGCAGAGTACGCCCGGCTCGCTGAGGATTTTGCGCAAAAATCCTC GGTCTACATCAAGGAAACTATGGCGCGCACCACTGCCGAGGACGCTATGAACGCTGCGCGCACCCGCCAC GCGTGGGCGAAAAATGAGCGCATCGATCGCGCCTATCCGACCGAGTATTTGCTCGCTAGCGAGGCTATCA AGACCGGAGGGCTCGCTTTTGACAGCAAGCAGTACGACGTAGCGCTCACGTGGGCGCGTAAGGCGTTGGA CGCACTCAAAAACGTAAAGCCTGAAAGTCAGTTGCTTGCAAAGGCCGCGAAGGAGGAGGCTGCGCGCAAG GCCGCCGAGGCACGAAAACTCGAAGAACAAAGAATTGCAGCCCAGAAAGCGCAGGAAGAACGTAAGCGTG CGGAGGAGGAAGCTGCGCGCAAGGCCGCCGAGGCACGAAAACTCGAAGAACAAAGAATTGCAGCCCAGAA AGCGCAGGAAGAACGTAAGCGTGCGGAGGAGGAAGCTGCGCGCAAGGCCGCCGAGGAAGCAGCGCGAAAG GCGGAGGAACTCGAGAAGGGTCGTGTGCTACCTGCGCAATACAAGGTGACTACGTGGTCCATTGACCGGG AATGTTTCTGGAATATTGCCAAAAACCCCGCCGTTTATGGCAACCCCTTCCTCTGGAAGAAGTTGTATGA GGCGAACAAGGACAAAATTCCTCAGTCCAAAAACCCCAATTGGGTAGAGCCTGAGACAGTCCTGGTCATC CCCAGTCTCAAGGGAGAGGAGCGCGAGGGTCTGTATGAGCCCAACGTGAAATACCGTCCTCTGCCGTA
Protein Sequence	>WP_010882214.1 membrane protein TmpB [Treponema pallidum] MKTRNFSLVSALYVLLGVPLFVSAASYDDNEFSRKSRAYSELAEKTYDAGEYDVSAEYARLAEDFAQKSS VYIKETMARTTAEDAMNAARTRHAWAKNERIDRAYPTEYLLASEAIKTGGLAFDSKQYDVALTWARKALD ALKNVKPESQLLAKAAKEEAARKAAEARKLEEQRIAAQKAQEERKRAEEEAARKAAEARKLEEQRIAAQK AQEERKRAEEEAARKAAEEAARKAEELEKGRVLPAQYKVTTWSIDRECFWNIAKNPAVYGNPFLWKKLYE ANKDKIPQSKNPNWVEPETVLVIPSLKGEEREGLYEPNVKYRPLP
Molecule Role	Protective antigen
Molecule Role Annotation	Treponema pallidum-susceptible guinea pigs of strain C4D were immunized with recombinant T. pallidum antigen TmpB. Guinea pigs receiving TmpB antigen demonstrated protection expressed by the development of significantly (P less than 0.01) smaller, atypical lesions of significantly (P less than 0.01) shorter duration and devoid of or containing fewer T. pallidum organisms than lesions in the remaining immunized and control animals (Wicher et al., 1991).
Related Vaccines(s)	T. pallidum TmpB Protein Vaccine
References

TmpB