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emm1
Gene Name	emm1
Sequence Strain (Species/Organism)	Streptococcus pyogenes
VO ID	VO_0012397
NCBI Nucleotide GI	311757
NCBI Protein GI	311758
Protein Accession	CAA44062.1
3D structure: PDB ID	2OTO
Other Database IDs	CDD:273479 CDD:291694 CDD:295219 CDD:279132 GOA:Q10372 HSSP: 1IC2 InterPro: IPR001899 InterPro: IPR005877 InterPro: IPR019931 InterPro: IPR019948 InterPro: IPR019950 UniProtKB/TrEMBL: Q10372
Taxonomy ID	1314
Gene Strand (Orientation)	?
Protein Name	M protein type 1
Protein pI	6.86
Protein Weight	52910.57
Protein Length	546
Protein Note	Gram-positive signal peptide, YSIRK family; TIGR01168
DNA Sequence	>gi\|311757\|emb\|X62131.1\| S.pyogenes emm1 (29/58) gene for M protein type 1 GGATCCAATGATAACATAAGGAGCATAAAAATGGCTAAAAATAACACGAATAGACACTATTCGCTTAGAA AATTAAAAACAGGAACGGCTTCAGTAGCGGTAGCTTTGACTGTTTTAGGGGCAGGTTTTGCGAATCAAAC AGAGGTTAAGGCTAACGGTGATGGTAATCCTAGGGAAGTTATAGAAGATCTTGCAGCAAACAATCCCGCA ATACAAAATATACGTTTACGTCACGAAAACAAGGACTTAAAAGCGAGATTAGAGAATGCAATGGAAGTTG CAGGAAGAGATTTTAAGAGAGCTGAAGAACTTGAAAAAGCAAAACAAGCCTTAGAAGACCAGCGTAAAGA TTTAGAAACTAAATTAAAAGAACTACAACAAGACTATGACTTAGCAAAGGAATCAACAAGTTGGGATAGA CAAAGACTTGAAAAAGAGTTAGAAGAGAAAAAGGAAGCTCTTGAATTAGCGATAGACCAGGCAAGTCGGG ACTACCATAGAGCTACCGCTTTAGAAAAAGAGTTAGAAGAGAAAAAGAAAGCTCTTGAATTAGCGATAGA CCAAGCGAGTCAGGACTATAATAGAGCTAACGTCTTAGAAAAAGAGTTAGATACGATTACTAGAGAACAA GAGATTAATCGTAATCTTTTAGGCAATCGAAAACTTGAACTTGATCAACTTTCATCTGAAAAAGAGCAGC TAACGATCGAAAAAGCAAAACTTGAGGAAGAAAAACAAATCTCAGACGCAAGTCGTCAAAGCCTTCGTCG TGACTTGGACGCATCACGTGAAGCTAAGAAACAGGTTGAAAAAGATTTAGCAAACTTGACTGCTGAACTT GATAAGGTTAAAGAAGACAAACAAATCTCAGACGCAAGCCGTCAAGGCCTTCGCCGTGACTTGGACGCAT CACGTGAAGCTAAGAAACAGGTTGAAAAAGATTTAGCAAACTTGACTGCTGAACTTGATAAGGTTAAAGA AGAAAAACAAATCTCAGACGCAAGCCGTCAAGGCCTTCGCCGTGACTTGGACGCATCACGTGAAGCTAAG AAACAAGTTGAAAAAGCTTTAGAAGAAGCAAACAGCAAATTAGCTGCTCTTGAAAAACTTAACAAAGAGC TTGAAGAAAGCAAGAAATTAACAGAAAAAGAAAAAGCTGAACTACAAGCAAAACTTGAAGCAGAAGCAAA TGTACTTAAAGATCCATTAGCGAAACAAGCTGAAGAACTCGCAAAACTAAGAGCTGGAAAAGCATCAGAC TCACAAACCCCTGATACAAAACCAGGAAACAAAGCTGTTCCAGGTAAAGGTCAAGCACCACAAGCAGGTA CAAAACCTAACCAAAACAAAGCACCAATGAAGGAAACTAAGAGACAGTTACCATCAACAGGTGAAACAGC TAACCCATTCTTCACAGCGGCAGCCCTTACTGTTATGGCAACAGCTGGAGTAGCAGCAGTTGTAAAACGC AAAGAAGAAAACTAAGCTGAATTC
Protein Sequence	>CAA44062.1 M protein type 1 [Streptococcus pyogenes] MAKNNTNRHYSLRKLKTGTASVAVALTVLGAGFANQTEVKANGDGNPREVIEDLAANNPAIQNIRLRHEN KDLKARLENAMEVAGRDFKRAEELEKAKQALEDQRKDLETKLKELQQDYDLAKESTSWDRQRLEKELEEK KEALELAIDQASRDYHRATALEKELEEKKKALELAIDQASQDYNRANVLEKELDTITREQEINRNLLGNR KLELDQLSSEKEQLTIEKAKLEEEKQISDASRQSLRRDLDASREAKKQVEKDLANLTAELDKVKEDKQIS DASRQGLRRDLDASREAKKQVEKDLANLTAELDKVKEEKQISDASRQGLRRDLDASREAKKQVEKALEEA NSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEANVLKDPLAKQAEELAKLRAGKASDSQTPDTKPGN KAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAAVVKRKEEN
Molecule Role	Protective antigen
Molecule Role Annotation	Mice were intranasally immunized with diphtheria toxoid (DT) conjugated polypeptides encompassing a conformational-constrained B cell epitope of the M1 protein (J8). Vaccinated mice were challenged 10 days after the last boost by the intranasal route. Animals had 60% protection against challenge (Schulze et al., 2006).
Related Vaccines(s)	S. pyogenes M Protein Vaccine
References

emm1