VIOLIN: Vaccine Investigation and Online Information Network

cna
Gene Name	cna
Sequence Strain (Species/Organism)	Staphylococcus aureus
VO ID	VO_0012389
NCBI Nucleotide GI	387879
NCBI Protein GI	WP_001039420
Protein Accession	AAA20874.1
3D structure: PDB ID	2F68
Other Database IDs	CDD:283410 CDD:283411 CDD:301706 CDD:212461
Taxonomy ID	1280
Gene Strand (Orientation)	?
Protein Name	Cna B-type domain-containing protein
Protein pI	6.09
Protein Weight	124972.57
Protein Length	1278
Protein Note	Collagen binding domain; pfam05737
DNA Sequence	>gi\|387879\|gb\|M81736.1\|STACNA Staphylococcus aureus collagen adhesin (cna) gene, complete cds ATGCACTTGTATTCGTTATACTGTATATATTTTGCATAATAAAATAATAATATGAATTTTTGATAAATTT CATTGAATAAGAACTAAATTAGTTTATAATTTATTATTAGTATCCTGTGGATATGACATAGAGTATAAGG AGGGGTTTTTATGAACAAAAATGTGTTGAAGTTTATGGTCTTTATAATGTTATTAAATATCATCACACCT TTATTTAATAAAAATGAAGCATTTGCAGCACGAGATATTTCATCAACGAATGTTACAGATTTAACTGTAT CACCGTCTAAGATAGAAGATGGTGGTAAAACGACAGTAAAAATGACGTTCGACGATAAAAATGGAAAAAT ACAAAATGGTGACATGATTAAAGTGGCATGGCCGACAAGCGGTACAGTAAAGATAGAGGGTTATAGTAAA ACAGTACCATTAACTGTTAAAGGTGAACAGGTGGGTCAAGCAGTTATTACACCAGACGGTGCAACAATTA CATTCAATGATAAAGTAGAAAAATTAAGTGATGTTTCGGGATTTGCAGAATTTGAAGTACAAGGAAGAAA TTTAACGCAAACAAATACTTCAGATGACAAAGTAGCTACGATAACATCTGGGAATAAATCAACGAATGTT ACGGTTCATAAAAGTGAAGCGGGAACAAGTAGTGTTTTCTATTATAAAACGGGAGATATGCTACCAGAAG ATACGACACATGTACGATGGTTTTTAAATATTAACAATGAAAAAAGTTATGTATCGAAAGATATTACTAT AAAGGATCAGATTCAAGGTGGACAGCAGTTAGATTTAAGCACATTAAACATTAATGTGACAGGTACACAT AGCAATTATTATAGTGGACAAAGTGCAATTACTGATTTTGAAAAAGCCTTTCCAGGTTCTAAAATAACTG TTGATAATACGAAGAACACAATTGATGTAACAATTCCACAAGGCTATGGGTCATATAATAGTTTTTCAAT TAACTACAAAACCAAAATTACGAATGAACAGCAAAAAGAGTTTGTTAATAATTCACAAGCTTGGTATCAA GAGCATGGTAAGGAAGAAGTGAACGGGAAATCATTTAATCATACTGTGCACAATATTAATGCTAATGCCG GTATTGAAGGTACTGTAAAAGGTGAATTAAAAGTTTTAAAACAGGATAAAGATACCAAGGCTCCTATAGC TAATGTAAAATTTAAACTTTCTAAAAAAGATGGATCAGTTGTAAAGGACAATCAAAAAGAAATTGAGATT ATAACAGATGCAAACGGTATTGCTAATATTAAAGCGTTGCCTAGTGGAGACTATATTTTAAAAGAAATAG AGGCGCCACGACCGTATACATTTGATAAGGATAAAGAATATCCGTTTACTATGAAAGATACAGATAATCA GGGATATTTTACGACTATTGAAAATGCAAAAGCGATAGAAAAAACAAAAGATGTTTCTGCTCAAAAGGTT TGGGAAGGCACTCAAAAAGTGAAACCAACGATTTATTTCAAGTTGTACAAACAAGATGACAATCAAAATA CAACACCAGTAGACAAAGCAGAGATTAAAAAATTAGAAGATGGAACGACAAAAGTGACATGGTCTAATCT TCCGGAAAATGACAAAAATGGCAAGGCTATTAAATATTTAGTTAAAGAAGTAAATGCTCAAGGTGAAGAT ACAACACCAGAAGGATATACTAAAAAAGAAAATGGTTTAGTGGTTACTAATACTGAAAAACCAATCGAAA CAACATCAATTAGTGGTGAAAAAGTATGGGACGACAAAGACAATCAAGATGGTAAGAGACCAGAAAAAGT CAGTGTGAATTTATTGGCTAACGGGGAGAAAGTAAAAACGTTAGACGTGACATCTGAAACAAACTGGAAG TACGAATTTAAAGACTTACCGAAGTATGATGAAGGAAAGAAAATAGAATATACAGTGACCGAAGATCACG TAAAAGACTACACAACAGACATCAACGGTACGACAATAACGAACAAGTATACACCAGGAGAGACATCGGC AACAGTAACAAAAAATTGGGATGACAATAATAACCAAGACGGAAAACGACCAACTGAAATCAAAGTTGAG TTATATCAAGATGGAAAAGCAACAGGAAAAACGGCAATATTAAATGAATCTAATAACTGGACACATACGT GGACAGGATTAGATGAAAAAGCAAAAGGACAACAAGTAAAATACACAGTCGAGGAATTAACAAAGGTCAA AGGTTATACAACACATGTGGATAACAATGATATGGGTAACTTGATTGTGACGAATAAATATACGCCAGAA ACAACATCAATTAGTGGTGAAAAAGTATGGGACGACAAAGACAATCAAGATGGTAAGAGACCAGAAAAAG TCAGTGTGAATTTATTGGCTGATGGAGAGAAAGTAAAAACGTTAGACGTGACATCTGAAACAAACTGGAA GTACGAATTTAAAGACTTACCGAAGTATGATGAAGGAAAGAAAATAGAATATACAGTGACCGAAGATCAC GTAAAAGACTACACAACAGACATCAACGGTACGACAATAACGAACAAGTATACACCAGGAGAGACATCGG CAACAGTAACAAAAAATTGGGATGACAATAATAACCAAGACGGAAAACGACCAACTGAAATCAAAGTTGA GTTATATCAAGATGGAAAAGCAACAGGAAAAACGGCAATATTAAATGAATCTAATAACTGGACACATACG TGGACAGGATTAGATGAAAAAGCAAAAGGACAACAAGTAAAATACACAGTCGAGGAATTAACAAAGGTCA AAGGTTATACAACACATGTGGATAACAATGATATGGGCAACTTGATTGTGACGAATAAATATACGCCAGA AACAACATCAATTAGTGGTGAAAAAGTATGGGACGACAAAGACAATCAAGATGGTAAGAGACCAGAAAAA GTCAGTGTGAATTTATTGGCTAACGGAGAGAAAGTAAAAACGTTAGACGTGACATCTGAAACAAACTGGA AGTACGAATTTAAAGACTTACCGAAGTATGATGAAGGAAAGAAAATAGAATATACAGTGACCGAAGATCA CGTAAAAGACTACACAACAGACATCAACGGTACGACAATAACGAACAAGTATACACCAGGAGAGACATCG GCAACAGTAACAAAAAATTGGGATGACAATAATAACCAAGACGGAAAACGACCAACTGAAATCAAAGTTG AGTTATATCAAGATGGAAAAGCAACAGGAAAAACGGCAATATTAAATGAATCTAATAACTGGACACATAC GTGGACAGGATTAGATGAAAAAGCAAAAGGACAACAAGTAAAATACACAGTCGATGAATTAACAAAAGTT AATGGCTATACAACGCATGTGGATAACAATGATATGGGTAACTTGATTGTGACAAATAAATATACGCCGA AAAAACCGAATAAACCAATCTATCCTGAAAAACCAAAAGACAAAACACCACCAACTAAACCTGATCATTC TAATAAAGTTAAACCAACTCCCCCAGATAAGCCATCAAAAGTGGATAAGGATGATCAACCTAAAGATAAT AAAACCAAACCTGAAAATCCTCTAAAAGAATTACCAAAAACTGGTATGAAGATTATAACTTCATGGATTA CATGGGTATTTATAGGTATATTGGGACTGTATTTAATTTTAAGAAAAAGATTTAACTCATAAACCATTAT AATTATTTTTATAGATAAGGCTATTCTTAGTTCTATGTATAATACATGTATATTAATAGGTCACTTTTAA TCTGTATGTAAGCAGACTAAGAGTGGCCTTTTAAACAAATAAAAAAA
Protein Sequence	>WP_001039420.1 Cna B-type domain-containing protein [Staphylococcus aureus] MNKNVLKFMVFIMLLNIITPLFNKNEALAARDISSTNVTDLTVSPTKIEDGGKTTVKMTFDDKSVKIQNG DTIKVAWPTSGTVKIEGYSKTVPLTVKGEQVGQAVITPDGATITFNDKVEKLSDVSGFAEFEVQGRNLTQ TNTSDDKVATITSGNKSTNVTVHKSEAGTSSVFYYKTGDMLPEDTTHVRWFLNINNEKRYVSKDITIKDQ IQGGQQLDLSTLNINVTGTHSNYYSGSNAITDFEKAFPGSKITVDNTKNTIDVTIPQGYGSYNSFSINYK TKITNEQQKEFVNNSQAWYQEHGKEEVNGKSFNHTVHNINANAGIEGTVKGELKVLKQDKDTKAPIANVK FKLSKKDGSVVKDNQKEIEIITDANGTANIKALPSGDYILKEIEAPAPYTFDKDKEYPFTMKDTDNQGYF TTIENAKEIEKTKDVSAQKVWEGTQKVKPTIYFKLYKQDDNQNTTPVDKAEIKKLEDGTTKVTWSNLPEN DKNGKTIKYLVKEVNAQGEDTTPEGYTKKENGLVVTNTEKPIETTSISGEKVWDDKDNQDGKRPEKVSVN LLANGEKVKTLDVTSETNWKYEFKNLPKYDEGKKIEYTVTEDHVKDYTTDINGTTITNKYTPGETSATVT KNWDDNNNQDGKRPTEIKVELYQDGKATGKTATLNESNNWTHTWAGLDEKAKGQQVKYTVEELTKVKGYT THVDNNDMGNLIVTNKYTPETTSISGEKVWDDKDNQDGKRPEKVSVNLLANGEKVKAVDVTSETNWKYEF KDLPKYDEGKKIEYTVTEDHVKDYTTDINGTTITNKYTPGETSATVTKNWDDNNNQDGKRPTEIKVELYQ DGKATGKTAKLNESNNWTHTWTGLDEKAKGQQVKYTVEELTKVKGYTTHVDNNDMGNLIVTNKYTPETTS INGEKVWDDKDNQDGKRPEKVSINLLANGEKVKTLDVTSETNWKYEFKDLPKYDEGKKIEYTVTEDHVKD YTTDINGTTITNKYTPGETSATVTKNWDDNNNQDGKRPTEIKVELYQDGKATGKTATLNESNNWTHTWAG LDEKAKGQQVKYTVEELTKVKGYTTHVDNNDMGNLIVTNKYTPEKPNKPIYPEKPKDKTPPTKPDHSNKV KPTPPDKPSKVDKDDQPKDNKTKPENPLKELPKTGMKIITSWITWVFIGILGLYLILRKRFNS
Molecule Role	Protective antigen
Molecule Role Annotation	Mice were immunized with a recombinant fragment of CNA protein, and were then challenged with the S. aureus clinical isolate strain Phillips. At 14 d after inoculation, mortality in the collagen adhesin-vaccinated group was only 13%, compared with 87% in the control antigen immunized group (Nilsson et al., 1998). Mice vaccinated with a combination of two Staphylococcus aureus antigens consisting of a recombinant collagen-binding protein (CnBP) and alpha-toxoid (alpha-toxoid) were significantly protected from intramammary challenge infection with S. aureus.(Mamo et al., 2000)
Related Vaccines(s)	S. aureus CNA Protein Vaccine , S. aureus DNA vaccine encoding Efb, FnbpA, ClfA, Cna
References

cna