VIOLIN: Vaccine Investigation and Online Information Network

PE20
Gene Name	PE20
Sequence Strain (Species/Organism)	Mycobacterium tuberculosis H37Rv
VO ID	VO_0012371
NCBI Gene ID	885537
NCBI Protein GI	57116919
Locus Tag	Rv1806
Genbank Accession	JLDD01000021
Protein Accession	YP_177843
Taxonomy ID	83332
Gene Starting Position	2048071
Gene Ending Position	2048370
Gene Strand (Orientation)	+
Protein Name	PE family protein PE20
Protein pI	4.19
Protein Weight	8927.3
Protein Length	99
Protein Note	Rv1806, (MTV049.28), len: 99 aa. Member of the Mycobacterium tuberculosis PE family of gly-, ala-rich proteins (see citation below), most similar to Rv1788\|MTV049.10\|AL022021 (99 aa), FASTA scores: opt: 334, E(): 4.7 e-15, (59.8% identity in 97 aa overlap). TBparse score is 0.932.
DNA Sequence	>NC_000962.3:2048071-2048370 Mycobacterium tuberculosis H37Rv, complete genome CATGGCGTTTGTTCTTGTCTGTCCAGATGCGCTGGCCATCGCGGCCGGTCAGTTGCGCCATGTTGGATCG GTGATAGCCGCGCGGAATGCGGTCGCGGCACCGGCAACTGCCGAATTGGCCCCGGCGGCCGCTGACGAAG TATCAGCTTTGACTGCAACACAATTCAACTTCCATGCCGCCATGTACCAAGCGGTCGGCGCCCAGGCGAT CGCCATGAATGAGGCGTTCGTCGCGATGTTGGGCGCCAGCGCGGATTCTTACGCGGCTACCGAAGCCGCC AACATCATTGCTGTGAGCTA
Protein Sequence	>YP_177843.1 PE family protein PE20 [Mycobacterium tuberculosis H37Rv] MAFVLVCPDALAIAAGQLRHVGSVIAARNAVAAPATAELAPAAADEVSALTATQFNFHAAMYQAVGAQAI AMNEAFVAMLGASADSYAATEAANIIAVS
Molecule Role	Protective antigen
Molecule Role Annotation	A selection of previously identified protective Mycobacterium tuberculosis DNA vaccines were re-formulated as proteins and administered with a Th1-inducing adjuvant to help stimulate the relevant immune responses necessary for protection. One candidate (Rv1806-1807) induced protection in the guinea pig aerosol infection model 30 days post-challenge on the basis of reducing the bacterial burden of M. tuberculosis in the lungs (Vipond et al., 2006).
Related Vaccines(s)	DNA vaccine Rv1806-1807
References

PE20