VIOLIN: Vaccine Investigation and Online Information Network

vacA
Gene Name	vacA
Sequence Strain (Species/Organism)	Helicobacter pylori
VO ID	VO_0011341
NCBI Protein GI	WP_123946465
Other Database IDs	CDD:111576 CDD:309066
Taxonomy ID	210
Gene Strand (Orientation)	?
Protein Name	autotransporter vacuolating cytotoxin VacA
Protein pI	9.4
Protein Weight	132293.35
Protein Length	1391
Protein Note	Vacuolating cyotoxin; pfam02691
Protein Sequence	>WP_123946465.1 autotransporter vacuolating cytotoxin VacA [Helicobacter pylori] MEIQQTHRKINRPLVSLVLAGALISAIPQQSHAAFFTTVIIPAIVGGIATGTAVGTVSGLLGWGLKQAEE ANKTPDKPDKVWRIQAGKGFNEFPNKEYDLYRSLLSSKIDGGWDWGNAATHYWVKGGQQNKLEVDMKDAV GTYKLSGLRNFTGGDLDVNMQKATLRLGQFNGNSFTSFKDSADRTTRVDFNAKNISIDNFVEINNRVGSG AGRKASSTVLTLQASEGITSSKNAEISLYDGATLNLASNSVKLNGNVWMGRLQYVGAYLAPSYSTINTSK VTGEVDFNHLTVGDKNAAQAGIIASNKTHIGTLDLWQSAGLNIIAPPEGGYKDKPKDKPSNTTQNNANNN QQNSAQNNSSTQVINPPNSAQKTEIQPTQVIDGPFAGGKDTVVNIDRINTKADGTIKVGGYKASLTTNAA HLHIGKGGVNLSNQASGRTLLVENLTGNITVDGPLRVNNQVGGYALAGSSANFEFKAGTDTKNGTATFNN DISLGRFVNLKVDAHTANFKGIDTGNGGFNTLDFSGVTGKVNINKLITASTNVAAKNFNINELIVKTNGV SVGEYTHFSEDIGSQSRINTVRLETGTRSIFSGGVKFKSGEKLVIDEFYYSPWNYFDARNIKNVEITRKF ASSTPENPWGTSKLMFNNLTLGQNAIMDYSQFSNLTIQGDFINNQGTINYLVRGGQVATLNVGNAAAMMF NNDIDSATGFYKPLIKINSAQDLIKNTEHVLLKAKIIGYGNVSTGTNGISNVNLEEQFKERLALYNNNNR MDTCVVRNTDDIKACGMAIGNQSMVNNPDNYKYLIGKAWKNIGISKTANGSKISVYYLGNSTPTENGGST TNLPTNTTNNARSANYALVKNAPFAHSATPNLVAINQHDFGTIESVFELANRSKDIDTLYTHSGAQGRDL LQTLLIDSHDAGYARTMIDATSANEITKQLNAATTTLNNIASLEHKTSGLQTLSLSNAMILNSRLVNLSR RHTNHIDSFAQRLQALKDQRFASLESAAEVLYQFAPKYEKPTNVWANAIGGASLNNGSNASLYGTSAGVD AFLNGNVEAIVGGFGSYGYSSFSNQANSLNSGANNANFGVYSRIFANQHEFDFEAQGALGSDQSSLNFKS ALLQDLNQSYNYLAYSATARASYGYDFAFFRNALVLKPSVGVGYNHLGSTNFKSNSQSQVALKNGASSQH LFNANANVEARYYYGDTSYFYMNAGVLQEFANFGSSNAVSLNTFKVNATHNPLNTHARVMMGGELKLAKE VFLNLGFVYLHNLISNIGHFASNLGMRYSF
Molecule Role	Protective antigen
Molecule Role Annotation	Treatment of the Helicobacter pylori vacuolating cytotoxin with very low concentrations of formaldehyde resulted in abrogation of toxic activity in both a HeLa cell vacuolation assay and an in vivo assay of gastric epithelial damage. Detoxification had only a minimal effect on the integrity of the oligomeric or monomeric structure. The toxoid retained the ability to bind to target cells and to induce high-titer neutralizing antibodies after immunization of rabbits. Furthermore, oral immunization of mice with the toxoid resulted in protection against infective challenge with mouse-adapted strains of H. pylori (Manetti et al., 1997).
Related Vaccines(s)	H. pylori VacA protein vaccine
References

vacA