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Rop2
Gene Name	Rop2
Sequence Strain (Species/Organism)	Toxoplasma gondii
VO ID	VO_0011340
NCBI Protein GI	115299638
3D structure: PDB ID	2W1Z
Other Database IDs	CDD:291215 CDD:304357
Taxonomy ID	5811
Gene Strand (Orientation)	?
Protein Name	Rop2 protein
Protein pI	9.64
Protein Weight	28699.38
Protein Length	316
Protein Note	Kinase-like; pfam14531
Protein Sequence	>ABI93795.1 Rop2 protein, partial [Toxoplasma gondii] LRLLRGIKNQKQAKVHLRFIFPFDLVKDPKKRKMIRVRLDERDMWVLSRFFLYPRMQSNLQMLGDVLLSH SSTHKSLVHHARLQLTLQLIRLLASLHHYGLVHADFQVSNILLDQRGGVFLTGFEHLVRDGASAVSPIGR GFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRSCKNIPQPVR ALLEGFLRYPKEDRLLPLQAMETPEYEQLRTELSAVLPLYQTDGEPA
Molecule Role	Protective antigen
Molecule Role Annotation	A study to examine the immunostimulatory properties of Leishmania infantum Hsp83 (83) to elicit humoral and cellular response against the Toxoplasma gondii Rop2 protein in an adjuvant-free vaccination system was conducted. Mice immunized with fusion Rop2-83 elicited a stronger humoral and cellular response in comparison to mice immunized with Rop2 alone, or a mix of LiHsp83 and Rop2. The fusion protein induced a Th1 type response, with predominance of specific IgG2a/IgG2c isotype and IFN-gamma secretions, whereas Rop2 alone or mixed with LiHsp83 produced a Th1/Th2 mixed response. Vaccination with fusion protein conferred a remarkable resistance against oral infection with ME49 cysts in C57BL/6 and C3H mice, in comparison to mice immunized with Rop2 alone or the protein mixture. Following lethal challenge, a significant survival rate was observed in Rop2-83 immunized Balb/c and C57BL/6 mice in comparison to control groups (Echeverria et al., 2006).
Related Vaccines(s)	T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2 , T. gondii Subunit Rop2-Hsp83 Fusion Protein Vaccine
References

Rop2