VIOLIN: Vaccine Investigation and Online Information Network

katA
Gene Name	katA
Sequence Strain (Species/Organism)	Helicobacter pylori
VO ID	VO_0011339
NCBI Protein GI	WP_000247320
3D structure: PDB ID	1QWL
Other Database IDs	CDD:163712
Taxonomy ID	210
Gene Strand (Orientation)	?
Protein Name	catalase
Protein pI	8.69
Protein Weight	55672.85
Protein Length	561
Protein Note	Clade 3 of the heme-binding enzyme catalase; cd08156
Protein Sequence	>WP_000247320.1 catalase [Helicobacter pylori] MVNKDVKQTTAFGAPVWDDNNVITAGPRGPVLLQSTWFLEKLAAFDRERIPERVVHAKGSGAYGTFTVTK DITKYTKAKIFSKVGKKTECFFRFSTVAGEKGSADAVRDPRGFAMKYYTEEGNWDLVGNNTPVFFIRDAI KFPDFIHTQKRDPQTNLPNPDMVWDFWSNVPESLYQVTWVMSDRGIPKSFRHMDGFGSHTFSLINAKGER FWVKFHFETMQGVKHLTNEEAAEVRKYDPDSNQRDLFDAIAGGDFPKWKMSIQVMPEEDAKKYRFHPFDV TKIWYLQDYPLMEVGIVELNKNPENYFAEVEQAAFTPANVVPGIGYSPDRMLQGRLFSYGDTHRYRLGVN YPQIPVNRPRCPFHSSSRDGYMQNGYYGSLQNYTPSSLPGYKEDKSARDPKFNLAHIEKEFEVWNWDYRA EDSDYYTQPGDYYRSLPADEKERLYDTIGGSLAHVTHKEIVDKQLEHFKKADPKYAEGVKKALEKHQKMM KDMHAKDMHHMKKKK
Molecule Role	Protective antigen
Molecule Role Annotation	Recombinant H. pylori catalase plus CT was used for immunization, and groups of mice were challenged with the Sydney strain of H. pylori. Immunization with recombinant catalase protected a significant proportion (9 of 10) of the mice from H. pylori challenge, indicating that this enzyme should be considered as a candidate for a future vaccine (Radcliff et al., 1997). Significant protection against H. pylori colonisation was induced with rSOD, rKatA and rTpx individually (Stent et al., 2012).
Related Vaccines(s)	H. pylori catalase protein vaccine
References

katA