VIOLIN: Vaccine Investigation and Online Information Network

hsp60
Gene Name	hsp60
Sequence Strain (Species/Organism)	Helicobacter pylori
VO ID	VO_0011336
NCBI Protein GI	397869
Other Database IDs	CDD:234573 CDD:239460 GOA:P42383 InterPro: IPR001844 InterPro: IPR002423 InterPro: IPR018370 UniProtKB/UniProt: P42383
Taxonomy ID	210
Gene Strand (Orientation)	?
Protein Name	heat shock protein 60
Protein pI	5.36
Protein Weight	53991.72
Protein Length	611
Protein Note	chaperonin GroEL; Reviewed; PRK00013
Protein Sequence	>CAA52062.1 heat shock protein 60 [Helicobacter pylori] MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGA QLVKEVASKTADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKASKKVGGK EEITQVATISANSDHNIGKLIADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKM TAQLDNAYILLTDKKISSMKDILPLLEKTMKEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGF GDRRKEMLKDIAILTGGQVISEELGLSLENAEVEFLGKAGRIVIDKDNTTIVDGKGHSDDVKDRVAQIKT QIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIR AAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVEKHEGHFGFNASNGKYVDMFKEGI IDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKATPAMPDMGGMGGMGGMGGMM
Molecule Role	Protective antigen
Molecule Role Annotation	Researchers prepared an oral liposome-encapsulated recombinant Helicobacter pylori (Hp) heat shock protein 60 (Hsp60) vaccine and investigate its effect against Hp infection in mice. rHsp60 plus CT (choleratoxin), liposome-encapsulated rHsp60 and liposome-encapsulated rHsp60 plus CT had protective rates against Hp infection of 73.3%, 66.7% and 86.7%, respectively (Huang et al., 2005). Oral therapeutic immunization with CWAE significantly reduced the number of H. pylori colonies in the stomach of Mongolian gerbils, compared with oral immunization using CTB-UE or H. pylori urease. The protection of CWAE was associated with higher levels of mixed CD4+ T cell (Th cell) response, IgG, and secretory IgA (sIgA) antibodies to H. pylori (Guo et al., 2017).
References

hsp60