VIOLIN: Vaccine Investigation and Online Information Network

pra
Gene Name	pra
Sequence Strain (Species/Organism)	Coccidioides immitis
VO ID	VO_0011333
NCBI Protein GI	42742528
Other Database IDs	CDD:128986 CDD:282710
Taxonomy ID	5501
Gene Strand (Orientation)	?
Protein Name	proline-rich antigen
Protein pI	3.93
Protein Weight	18554.97
Protein Length	254
Protein Note	eight cysteine-containing domain present in fungal extracellular membrane proteins; smart00747
Protein Sequence	>AAS45282.1 proline-rich antigen [Coccidioides immitis] MQFSHALIALVAAGLASAQLPDIPPCALNCFVEALGNDGCTRLTDFKCHCSKPELPGQITPCVEEACPLD ARISVSNIVVDQCSKAGVPIEIPPVDTTAAPEPSETAEPTAEPTEEPTAEPTAEPTAEPTHEPTEEPTAV PTGTGGGVPTGTGSFTVTGRPTASTPAEFPGAGSNVRASVGGIAAALLGLAAYL
Molecule Role	Protective antigen
Molecule Role Annotation	C57BL6 mice were immunized with syngeneic, bone marrow-derived DCs (JAWS II cells) transfected with a cDNA encoding the protective Coccidioides-Ag2/proline-rich Ag (pra). The immunized mice were lethally challenged with C. posadasii through either an i.p. or intranasal route. Upon necropsy after 10 days of infection, fungal burden in lung and spleen of immunized mice was significantly reduced as compared with the control animals. The lung tissue homogenates of immunized animals showed higher levels of IFN-gamma. Histologically, lung tissues of immunized mice were in better condition than the control mice (Awasthi et al., 2005).
Related Vaccines(s)	C. posadasii DNA Vaccine encoding PRA Protein
References