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PEP1

Gene Name PEP1
Sequence Strain (Species/Organism) Coccidioides posadasii
VO ID VO_0011325
NCBI Protein GI 73915320
Other Database IDs CDD:299705
CDD:278455
CDD:133137
Taxonomy ID 199306
Gene Strand (Orientation) ?
Protein Name aspartyl protease 1
Protein pI 4.43
Protein Weight 42071.91
Protein Length 463
Protein Note Cellular and retroviral pepsin-like aspartate proteases; cl11403
Protein Sequence 
>AAZ92541.1 aspartyl protease 1 [Coccidioides posadasii]
MRNSILLAATVLLGCTSAKVHKLKLKKLPLTEQLEYGDIETHVRALGQKYFGSLPSSQQQTVLSDEYSTT
DGHNVLVDNFLNAQYFSEISIGNPPQNFKVVLDTGSSNLWVPSSECGSIACYLHNKYDSSASSTYKKNGT
EFAIRYGSGSLSGFVSQDTLRIGDLTIEGQDFAEATNEPGLAFAFGRFDGILGLGYDTISVNKIVPPFYN
MINEGLIDEPVFGFYLGDTNKEGDDSYATFGGVDSSLFSGEMIKIPLRRKAYWEVDFDAIAFGNERAELE
DTGIILDTGTSLIALPSTLAELLNREIGAKKSWNGQYTVDCNKRPSLPDLTFTLSGHNFTIGPYDYILEV
QGSCISSFMGMDFPEPVGPLAILGDAFLRRFYTMYDLGNNLVGLAKAGN
Molecule Role Protective antigen
Molecule Role Annotation Groups of C57BL/6 mice (20 per group) vaccinated with rPep1 (1 µg or 5 µg per dose) plus adjuvant and challenged with an intranasal inoculum began to die at about 14 to 16 days but then showed significantly greater survival than the control mice (Tarcha et al., 2006).
References