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Gal/GalNAc lectin

Gene Name Gal/GalNAc lectin
Sequence Strain (Species/Organism) Entamoeba histolytica HM-1:IMSS
VO ID VO_0011323
NCBI Gene ID 3404842
NCBI Protein GI 67469085
Locus Tag EHI_046650
Genbank Accession DS571321
Protein Accession XP_650534
Taxonomy ID 294381
Chromosome No Unknown
Gene Starting Position 16307
Gene Ending Position 19930
Gene Strand (Orientation) -
Protein pI 4.63
Protein Weight 126939.55
Protein Length 1207
Protein Note transcript EHI_046650A
DNA Sequence 
>NW_001915036.1:16307-19930 Entamoeba histolytica HM-1:IMSS scf_1104750517013 genomic scaffold, whole genome shotgun sequence
ATTATCCATTGAAATTAGCATTTGTGGCATTATCATCTTTAGCTGTGAATTGTGGGTTATTCACAGTATT
ATCAACAGTATTCTTTCTTGCAGAAATAACAATATCAACAGTTTGCTTAATTCCAATAGCAATAATTACC
ATAACAACAACAATTACTGCAACAACAACTGCAACAGTGGTACCAGCAGCAATAGCAGCTGTATTATCAA
CGTCTTGCCATAACAAACAAACAGCATCTTTATCAACCAATTCATCATTGATCTTACAATTACCACATGC
ATCTAATGAGAATCTATGATCTGCATAATCAGAGTACATTGTTAAAATCCACCCACTTTCAGATTGTAAT
GAACATTCACAATAGAAACAATTCTTAGCTGCTTTAGACATATTAGGGAATTGAATATCAATATCACATT
GAACAAAATTAGTTTCAATTTCTCCTGTTTCTTTGTCACAATAAGCGTCTTGACATTTATTCTTATAGAG
CAATGCTTTTTCATGTCCATCAATATTACTTGTCCATTTATGTGTTATCACTCCTTCAGTGATAGTTTCA
ACACAGGTATAATTATAACATTTATCAGTACAATCCCTATCATTAGATGGCTCATCACTACATTTTGTAA
ATTCCTTCTTGATACAATATCCTGTACTTGTATCACATTTACCTGTTAATGAAGCACACCCAACATCAGC
AGTATTTGATGAACAAATAGAATCATCATACACACCACTACATTTTGGAATACTTCCAGAAGCATCACAA
TTAGTTTTCATACAAATAACTTCTCCAGGTTTACTAGGAGGAAGTGATGGACAAATAGTGACATTAGTTG
GTTCACAAAGTTGGGATGTTCCAGTCTTTACTTGAATGAAACAATTATTAGTTGGATTACAATCTCCTTC
ATATTTACAATCCCCATCTGAACAAGTCATCTGATAAATATTTCCAGATGCATCTACTTGATTTGGACAT
TTATCAACAAGAGTAGACTCTTTATCCATTCCACTACAATACTTACATAAACTTTTTACCTTTTCTTCGT
TTGAATTCCATTCACATTTATATTCATCAAATGTTGTGCCAATAATTAATTTGTAATCAAGAACATCAAG
ACATTTACTAGGGAAATTCTCATGTTTAGTACAATCAAATTCATCATCAATATGACAACTTCCATCACGA
CATACATATGGAATACCATTTATATTCTTTTTATTAGTACAATCCATTTTAATAAGTTTAGCTGGGTCAA
CAAGAATATTATCATATGAACAATACATACACTGACTATCTAAAATAACTTTTGATCCATCTTTTACAAT
AACTTTACATTCTCCATTTGCATATTCCCATTCATAATATTGTTCACAATCACTTAATCTATCTTTGAAA
AGATCTTTACAATCATATTCATCTGGTGCTTGACATTCTCCATCTTTACAAACAAATGGAATTCCTTGTG
ATGTAGTCAAACCTTCACATTTATTAACAATTTCATTTCCATCACAAATTTTACATTCTTGAATTGCTTT
ATCTGTAGTTACAAGTATACATTCTCTATTTCCACTACATACATAATTAGCATATCCATCACATTTTTCA
GGTACTTTTTCTTTACATACATATTCCTCTTGGTCTACAACATATTGAGTCGTTCCATTAGCAGTATATT
CTTTACAGACTTTTTTGTAACAACCTTCCCAAACAATATCATGTCCTTTAAGCTCTTCACAATTATCAAC
ATTAATACATTTTGGATCCCCATCTGTATAATCACAAACTTCGCCATTAGTACATCCATTACTAGTATCA
CATTTACATTGATATGATGTAGATGCATCACATCGACAATTTCCATTAACTTTCCCACACACTTTCATTC
CAGAACTACATCCAACTAAATTCATAACACAATTTCCAGTTTCACTATCACATGTAGCTTCATAACATGG
ATTTTCTTCATATGGAGATACTTTAATACATTTCTTTTCTTGAACCATACATGTTCCAGCAGAACAATAA
TATTCTTCACACTTACTTGATAATTTAGGACAATAGCTAGATGATTGTAATGTATTTGGAATACATTCTC
CATTTGTTCTATCACATGAATAAGTTCTACAAACAAATTTTTCTACTCCAGATTCAATAATTGAAGATGG
CTTAATATCATCAGTACAATTACTTCTAAAAGCACAGTTGTTTCCTGAACAATAAGGCTCTAAACATTTA
ACTGTTGAAACACATTTATTTTGTTCAATAGTACATCCAATATCTTCAACACATTTAGCTACACCTAAAC
AACTTTCTGTTGTACATTTTCTTTTTTCAATTTTATGATCAGCACTTGGATAATAAACACATTCTCCATT
TTCAGTATTACATGTTGTATAATAACATTCACTATGACAACACATTGGACATGTACAACGAGCCCCACCA
TCACAAAATCCTTTACAAGTTTTTCTATCACATAATTCAGTATTATTTGCCATAATAGTATTATATAATT
GTGGAAGAGAAGTGCTTAATGATGAAACAGATGATTTAAAGTAATGTTCCCCTTTATTAACTAATTCTTC
AAGTTGATATTCTTCTTCAATTGATGAGTCTAAATTAAATACATAAAATGTAGTATTATGACTATAAAGA
GTATTTAACATATTAGAAGCTTTTCCTGCATATTTACTGATATAAACAATATTCTTTCCTGCTTTTGAAG
ACATTTGGTTATATACAGTTTCTATAGCTTTTGTTTCATTTCCTTTTCTCATAACAGTAATTCCATTTAA
TACATTTTTAATATTATCCTTTGTTACTAATGAATCTGAATGATATGGATTTTGAGAGTTAATATAATAA
GCGAATGAAGTATCATTTGGGAATAAATCAATCAAATAATTAACAATTGAACTAAATATATTTCTTAATG
TATTAGTCATATCTAAATTAACAACAATACCAACCGCCATATTATTTGTTGGTGGTAAAACAGTAGAAGC
ATGACATTTAGTAATATTATTATTTTTATAGTCAGTGATAAAATTATCAGAAAATTCTGAACTACTTCTA
AATGTAATAACTTTACCTCCAATATATTCAAATCTACATGGTGACATTCCTTCTGCATATTTATTTGTTA
CATCATATGTTTTTTCAAGAAAATATGCAGCTGTTAATGGTGGTTTAGCAGCATATTTATAACAAGTTAA
TCCATTAATTGAAACAACTGGTAATTTAGAAGTATCTGATGGAATACGAGACCAATCCAATTGATATTCT
CTAATAGGATATCCCATTTTCTTTCTACACATATTTTCTTCTTTTGTATCACTTTTATCACGGTCATAAT
CTTGATTAAATATCATTTCAGTAAAATATTTACTTTGGTCTTTAGTAGGAAAATTACTATCAATAGTTGT
CCATTCTAAATTTCTCCATGGTTGCATTGTTAAATAATAAAATACACTATACTTTTTATTTACACTTCTT
GACCATGAAGCTGCATTTTTACCCATTCCCATTCTTCCTTTATCTTGGATATCTACAGTTCCAGAAAACT
CATTTAAATTAATTCCTAAAGCAATTGAAGCATAAAATAATACCAAAATTATCA
Protein Sequence 
>XP_650534.1 Gal/GalNAc lectin heavy subunit, putative [Entamoeba histolytica HM-1:IMSS]
MIILVLFYASIALGINLNEFSGTVDIQDKGRMGMGKNAASWSRSVNKKYSVFYYLTMQPWRNLEWTTIDS
NFPTKDQSKYFTEMIFNQDYDRDKSDTKEENMCRKKMGYPIREYQLDWSRIPSDTSKLPVVSINGLTCYK
YAAKPPLTAAYFLEKTYDVTNKYAEGMSPCRFEYIGGKVITFRSSSEFSDNFITDYKNNNITKCHASTVL
PPTNNMAVGIVVNLDMTNTLRNIFSSIVNYLIDLFPNDTSFAYYINSQNPYHSDSLVTKDNIKNVLNGIT
VMRKGNETKAIETVYNQMSSKAGKNIVYISKYAGKASNMLNTLYSHNTTFYVFNLDSSIEEEYQLEELVN
KGEHYFKSSVSSLSTSLPQLYNTIMANNTELCDRKTCKGFCDGGARCTCPMCCHSECYYTTCNTENGECV
YYPSADHKIEKRKCTTESCLGVAKCVEDIGCTIEQNKCVSTVKCLEPYCSGNNCAFRSNCTDDIKPSSII
ESGVEKFVCRTYSCDRTNGECIPNTLQSSSYCPKLSSKCEEYYCSAGTCMVQEKKCIKVSPYEENPCYEA
TCDSETGNCVMNLVGCSSGMKVCGKVNGNCRCDASTSYQCKCDTSNGCTNGEVCDYTDGDPKCINVDNCE
ELKGHDIVWEGCYKKVCKEYTANGTTQYVVDQEEYVCKEKVPEKCDGYANYVCSGNRECILVTTDKAIQE
CKICDGNEIVNKCEGLTTSQGIPFVCKDGECQAPDEYDCKDLFKDRLSDCEQYYEWEYANGECKVIVKDG
SKVILDSQCMYCSYDNILVDPAKLIKMDCTNKKNINGIPYVCRDGSCHIDDEFDCTKHENFPSKCLDVLD
YKLIIGTTFDEYKCEWNSNEEKVKSLCKYCSGMDKESTLVDKCPNQVDASGNIYQMTCSDGDCKYEGDCN
PTNNCFIQVKTGTSQLCEPTNVTICPSLPPSKPGEVICMKTNCDASGSIPKCSGVYDDSICSSNTADVGC
ASLTGKCDTSTGYCIKKEFTKCSDEPSNDRDCTDKCYNYTCVETITEGVITHKWTSNIDGHEKALLYKNK
CQDAYCDKETGEIETNFVQCDIDIQFPNMSKAAKNCFYCECSLQSESGWILTMYSDYADHRFSLDACGNC
KINDELVDKDAVCLLWQDVDNTAAIAAGTTVAVVVAVIVVVMVIIAIGIKQTVDIVISARKNTVDNTVNN
PQFTAKDDNATNANFNG
Molecule Role Protective antigen
Molecule Role Annotation Study tested if vaccination with the E. histolytica Gal/GalNAc lectin could prevent cecal infection in a C3H mouse model of amebic colitis. Vaccination prevented intestinal infection with efficacies of 84 and 100% in the two native lectin trials and 91 and 34% in the two LecA trials. Results show for the first time that immunization with the Gal/GalNAc lectin can prevent intestinal amebiasis in mice (Houpt et al., 2004).
Related Vaccines(s) E. histolytica Gal/GalNAc lectin protein vaccine
References