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gEh29
Gene Name	gEh29
Sequence Strain (Species/Organism)	Entamoeba histolytica
VO ID	VO_0011322
NCBI Nucleotide GI	399673
NCBI Protein GI	399674
Protein Accession	CAA50324.1
Other Database IDs	CDD:223527 CDD:239313 GOA:P19476 InterPro: IPR000866 InterPro: IPR012335 InterPro: IPR012336 InterPro: IPR017936 InterPro: IPR019479 UniProtKB/UniProt: P19476
Taxonomy ID	5759
Gene Strand (Orientation)	?
Protein Name	alkyl hydroperoxide reductase
Protein pI	7.38
Protein Weight	25237.95
Protein Length	304
Protein Note	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]; COG0450
DNA Sequence	>gi\|399673\|emb\|X70996.1\| E.histolytica gEh29 gene for alkyl-hydroperoxidase reductase TTAGTTAAAAAGTATTTGATGACTTATTAGTTCATGTTACATATACAAAAATAATACTTTTATTGAAGTT TTGTGCCAATACATTTCTCTTTCTCCTCATCATATTCTTCATTAGATTCTTTGAGAATGTGTGGATGTGT GTATCTCCGTTTTCTTCTTTTTATCTAGTCATTTTTGTTTTCTATTTACCAGTTCTTTCATTATAAGTTG TTTAAATGTTGAATAATTACCATAATGAGAATAATGCAGAAGTGATGATGACGACATTTTTATTTTAGTT AAGTAAAGATGATTTTGGTAGTTCATTTGTCATTTAAACATCTCATCATCACCACAATCTCATCAATTCA ATCAGTCAAATGTCTTGCAATCAACAAAAAGAGTGTTGTAAAAAAGAATGTCAAGAGAAAGAATGTTGTA AAGAATGTTGTTGTCCAAGAATAAAAGCATTTAAGAAATTTATAAACACATTTGAAAAAGCACAAATTGG AAAAGAAGCACCAGAATTTAAAGCACCAGCATATTGTCCATGTGGTTCAATCAAAGAGATTGATATTAAT GAATATAGAGGAAAATATGTTGTATTGTTGTTTTATCCATTGGATTGGACATTTGTTTGTCCAACAGAAA TGATTGGATATAGTGAACTTGCAGGACAATTGAAAGAAATCAATTGTGAAGTTATTGGAGTGAGTGTAGA TTCAGTTTATTGTCATCAAGCATGGTGTGAAGCAGATAAAAGTAAAGGAGGAGTAGGAAAGTTGACATTC CCATTAGTATCAGATATTAAGAGATGCATTTCTATCAAATATGGAATGTTAAATGTCGAAGCAGGAATTG CAAGAAGAGGATATGTCATCATTGACGATAAAGGAAAAGTAAGATACATTCAAATGAATGATGATGGAAT TGGAAGATCAACGGAAGAAACAATCAGAATAGTGAAAGCAATTCAATTCAGTGATGAACATGGAGCAGTT TGTCCACTCAATTGGAAACCAGGCAAAGACACCATTGAACCAACACCAGATGGAATTAAGAAATATTTAA CAGCACATTAAAACAAACAAGATAATTTAATACAAATTATTTTATGTTTTATAAGAAGAAAATGATATAA TAAAAGATAAA
Protein Sequence	>CAA50324.1 alkyl hydroperoxide reductase [Entamoeba histolytica] MSCNQQKECCKKECQEKECCKECCCPRIKAFKKFINTFEKAQIGKEAPEFKAPAYCPCGSIKEIDINEYR GKYVVLLFYPLDWTFVCPTEMIGYSELAGQLKEINCEVIGVSVDSVYCHQAWCEADKSKGGVGKLTFPLV SDIKRCISIKYGMLNVEAGIARRGYVIIDDKGKVRYIQMNDDGIGRSTEETIRIVKAIQFSDEHGAVCPL NWKPGKDTIEPTPDGIKKYLTAH
Molecule Role	Protective antigen
Molecule Role Annotation	80% of C3H/HeJ mice immunized with Eh29 administered in combination with a subclinical dose of whole cholera toxin, but not as an Eh29-CTxB fusion, showed no evidence of infection in tissue sections harvested following intracecal challenge with virulent E. histolytica trophozoites. These results suggest that Eh29 is capable of inducing protective anti-amoebic immune responses in mice following oral immunization and could be used in the development of oral vaccines against amoebiasis (Carrero et al., 2010).
Related Vaccines(s)	E. histolytica Eh29 protein vaccine
References

gEh29