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RVFVsMgp1 M protein
Gene Name	RVFVsMgp1 M protein
Sequence Strain (Species/Organism)	Rift Valley fever virus
VO ID	VO_0011318
NCBI Gene ID	956559
NCBI Protein GI	27881464
Locus Tag	RVFVsMgp1
Genbank Accession	M25276
Protein Accession	NP_777376
Taxonomy ID	11588
Gene Starting Position	20
Gene Ending Position	3613
Gene Strand (Orientation)	+
Protein Name	M protein
Protein pI	7.46
Protein Weight	122468.33
Protein Length	1197
DNA Sequence	>NC_002044.2:20-3613 Rift Valley fever virus M segment, complete sequence AATGTATGTTTTATTAACAATTCTAACCTCGGTTCTGGTGTGTGAAGCGATTATTAGAGTGTCTCTAAGC TCCACAAGAGAAGAGACCTGCTTTGGTGACTCCACTAACCCAGAGATGATTGAAGGAGCTTGGGATTCAC TCAGAGAGGAGGAGATGCCGGAGGAGCTCTCCTGTTCTATATCAGGCATAAGAGAGGTTAAGACCTCAAG CCAGGAGTTATACAGGGCATTAAAAGCCATCATTGCTGCTGATGGCTTGAACAACATCACCTGCCATGGT AAGGATCCTGAGGACAAGATTTCCCTCATAAAGGGTCCTCCTCACAAAAAGCGGGTGGGGATAGTTCGGT GTGAGAGACGAAGAGATGCTAAGCAAATAGGGAGAAAAACCATGGCAGGGATTGCAATGACAGTCCTTCC AGCCTTAGCAGTTTTTGCTTTGGCACCTGTTGTTTTTGCTGAAGACCCCCATCTCAGAAACAGACCAGGG AAGGGGCACAACTACATTGACGGGATGACTCAGGAGGATGCCACATGCAAACCTGTGACATATGCTGGGG CATGTAGCAGTTTTGATGTCTTGCTTGAAAAGGGAAAATTTCCCCTTTTCCAGTCGTATGCTCATCATAG AACTCTACTAGAGGCAGTTCACGACACCATCATTGCAAAGGCTGATCCACCTAGCTGTGACCTTCTGAGT GCTCATGGGAACCCCTGCATGAAAGAGAAACTCGTGATGAAGACACACTGTCCAAATGACTACCAGTCAG CTCATCACCTCAACAATGACGGGAAAATGGCTTCAGTCAAGTGCCCTCCTAAGTATGAGCTCACTGAAGA CTGCAACTTTTGTAGGCAGATGACAGGTGCTAGCCTGAAGAAGGGGTCTTATCCTCTCCAAGACTTGTTT TGTCAGTCAAGTGAGGATGATGGATCAAAATTAAAAACAAAAATGAAAGGGGTCTGCGAAGTGGGGGTTC AAGCACTCAAAAAGTGTGATGGCCAACTCAGCACTGCACATGAGGTTGTGCCCTTTGCAGTGTTTAAGAA CTCAAAGAAGGTTTATCTTGATAAGCTTGACCTTAAGACTGAGGAGAATCTGCTACCAGACTCATTTGTC TGTTTCGAGCATAAGGGACAGTACAAAGGAACAATGGACTCTGGTCAGACTAAGAGGGAGCTCAAAAGCT TTGATATCTCTCAGTGCCCCAAGATTGGAGGACATGGTAGTAAGAAGTGCACTGGGGACGCAGCATTTTG CTCTGCTTATGAGTGCACTGCTCAGTACGCCAATGCCTATTGTTCACATGCTAATGGGTCAGGGATTGTG CAGATACAAGTATCAGGGGTCTGGAAGAAGCCTTTATGTGTAGGGTATGAGAGAGTGGTTGTGAAGAGAG AACTCTCTGCCAAGCCCATCCAGAGAGTTGAGCCTTGCACAACTTGTATAACCAAATGTGAGCCTCATGG ATTGGTTGTCCGATCAACAGGGTTCAAGATATCATCAGCAGTTGCTTGTGCTAGCGGAGTTTGCGTCACA GGATCGCAGAGTCCTTCCACCGAGATTACACTCAAGTATCCAGGGATATCCCAGTCTTCTGGGGGGGACA TAGGGGTTCACATGGCACACGATGATCAGTCAGTTAGCTCCAAAATAGTAGCTCACTGCCCTCCCCAGGA CCCGTGCTTAGTGCATGACTGCATAGTGTGTGCTCATGGCCTGATAAATTACCAGTGTCACACTGCTCTC AGTGCCTTTGTTGTTGTGTTTGTATTCAGTTCTATTGCAATAATTTGTTTAGCTATTCTTTATAGGGTGC TTAAGTGCCTGAAGATTGCCCCAAGGAAAGTTCTGAATCCACTAATGTGGATCACAGCCTTCATCAGATG GATATATAAGAAGATGGTTGCCAGAGTGGCAGACAACATTAATCAAGTGAACAGGGAAATAGGATGGATG GAAGGAGGTCAGTTGGTTCTAGGGAACCCTGCCCCTATTCCTCGTCATGCCCCAATCCCACGTTATAGCA CATACCTGATGTTATTATTGATTGTCTCATATGCATCAGCATGTTCAGAACTGATTCAGGCAAGCTCCAG AATCACCACTTGCTCTACAGAGGGTGTTAACACCAAGTGTAGACTGTCTGGCACAGCATTGATCAGAGCA GGGTCAGTTGGGGCAGAGGCTTGTTTGATGTTGAAGGGGGTCAAGGAAGATCAAACCAAGTTCTTAAAGT TAAAAACTGTCTCAAGTGAGCTATCATGCAGGGAGGGCCAGAGTTATTGGACTGGGTCCTTTAGCCCTAA ATGTTTGAGCTCAAGGAGATGCCACCTTGTCGGGGAATGCCATGTGAATAGGTGTCTGTCTTGGAGGGAC AATGAAACTTCAGCAGAGTTTTCATTTGTTGGGGAAAGCACGACCATGCGAGAGAATAAGTGTTTTGAGC AATGTGGAGGATGGGGGTGTGGGTGTTTCAATGTGAACCCATCTTGCTTATTTGTGCACACGTATCTGCA GTCAGTTAGAAAAGAGGCCCTTAGAGTTTTTAACTGTATCGACTGGGTGCATAAACTCACTCTAGAGATC ACAGACTTTGATGGCTCTGTTTCAACAATAGACTTGGGAGCATCATCTAGCCGTTTCACAAACTGGGGTT CAGTTAGCCTCTCACTGGACGCAGAGGGCATTTCAGGCTCAAATAGCTTTTCTTTCATTGAGAGCCCAGG CAAAGGGTATGCAATTGTTGATGAGCCATTCTCAGAAATTCCTCGGCAAGGGTTCTTGGGGGAGATCAGG TGCAATTCAGAGTCCTCAGTCCTGAGTGCTCATGAATCATGCCTTAGGGCACCAAACCTTATCTCATACA AGCCCATGATAGATCAATTGGAGTGCACAACAAATCTGATTGATCCCTTTGTTGTCTTTGAGAGGGGTTC TCTGCCACAGACAAGGAATGACAAAACCTTTGCAGCTTCAAAAGGAAATAGAGGTGTTCAAGCTTTCTCT AAGGGCTCTGTACAAGCTGATCTAACTCTGATGTTTGACAATTTTGAGGTGGACTTTGTGGGAGCAGCCG TATCTTGTGATGCCGCCTTCTTAAATTTGACAGGTTGCTATTCTTGCAATGCAGGGGCCAGGGTCTGCCT GTCTATCACATCCACAGGAACTGGATCTCTCTCTGCCCACAATAAGGATGGGTCTCTGCATATAGTCCTT CCATCAGAGAATGGAACAAAAGACCAGTGTCAGATACTACACTTCACTGTGCCTGAAGTAGAGGAGGAGT TTATGTACTCTTGTGATGGAGATGAGCGGCCTCTGTTGGTGAAGGGGACCCTGATAGCCATTGATCCATT TGATGATAGGCGGGAAGCAGGGGGGGAATCAACAGTTGTGAATCCAAAATCTGGATCTTGGAATTTCTTT GACTGGTTTTCTGGACTCATGAGTTGGTTTGGAGGGCCTCTTAAAACTATACTCCTCATTTGCCTGTATG TTGCATTATCAATTGGGCTCTTTTTCCTCCTTATATATCTTGGAGGAACAGGCCTCTCTAAAATGTGGCT TGCTGCCACTAAGAAGGCCTCATA
Protein Sequence	>NP_777376.1 M protein [Rift Valley fever virus] MYVLLTILTSVLVCEAIIRVSLSSTREETCFGDSTNPEMIEGAWDSLREEEMPEELSCSISGIREVKTSS QELYRALKAIIAADGLNNITCHGKDPEDKISLIKGPPHKKRVGIVRCERRRDAKQIGRKTMAGIAMTVLP ALAVFALAPVVFAEDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDVLLEKGKFPLFQSYAHHR TLLEAVHDTIIAKADPPSCDLLSAHGNPCMKEKLVMKTHCPNDYQSAHHLNNDGKMASVKCPPKYELTED CNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKN SKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGTMDSGQTKRELKSFDISQCPKIGGHGSKKCTGDAAFC SAYECTAQYANAYCSHANGSGIVQIQVSGVWKKPLCVGYERVVVKRELSAKPIQRVEPCTTCITKCEPHG LVVRSTGFKISSAVACASGVCVTGSQSPSTEITLKYPGISQSSGGDIGVHMAHDDQSVSSKIVAHCPPQD PCLVHDCIVCAHGLINYQCHTALSAFVVVFVFSSIAIICLAILYRVLKCLKIAPRKVLNPLMWITAFIRW IYKKMVARVADNINQVNREIGWMEGGQLVLGNPAPIPRHAPIPRYSTYLMLLLIVSYASACSELIQASSR ITTCSTEGVNTKCRLSGTALIRAGSVGAEACLMLKGVKEDQTKFLKLKTVSSELSCREGQSYWTGSFSPK CLSSRRCHLVGECHVNRCLSWRDNETSAEFSFVGESTTMRENKCFEQCGGWGCGCFNVNPSCLFVHTYLQ SVRKEALRVFNCIDWVHKLTLEITDFDGSVSTIDLGASSSRFTNWGSVSLSLDAEGISGSNSFSFIESPG KGYAIVDEPFSEIPRQGFLGEIRCNSESSVLSAHESCLRAPNLISYKPMIDQLECTTNLIDPFVVFERGS LPQTRNDKTFAASKGNRGVQAFSKGSVQADLTLMFDNFEVDFVGAAVSCDAAFLNLTGCYSCNAGARVCL SITSTGTGSLSAHNKDGSLHIVLPSENGTKDQCQILHFTVPEVEEEFMYSCDGDERPLLVKGTLIAIDPF DDRREAGGESTVVNPKSGSWNFFDWFSGLMSWFGGPLKTILLICLYVALSIGLFFLLIYLGGTGLSKMWL AATKKAS
Molecule Role	Protective antigen
Molecule Role Annotation	The glycoprotein (GP) and nucleocapsid (NC) genes of Rift Valley fever virus (RVFV) were expressed in different expression systems and were evaluated for their ability to protect mice from virulent challenge using a prime-boost regime. Mice vaccinated with a lumpy skin disease virus-vectored recombinant vaccine (rLSDV-RVFV) expressing the two RVFV glycoproteins (G1 and G2, expressed by the RVFV M Segment) developed neutralising antibodies and were fully protected when challenged, as were those vaccinated with a crude extract of truncated G2 glycoprotein (tG2) (Wallace et al., 2006).
Related Vaccines(s)	RVF MP-12
References

RVFVsMgp1 M protein