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G glycoprotein

Gene Name G glycoprotein
Sequence Strain (Species/Organism) Hendra henipavirus
VO ID VO_0011310
NCBI Gene ID 1446471
NCBI Protein GI 29468607
Locus Tag Hvgp5
Genbank Accession AF017149
Protein Accession NP_047112
3D structure: PDB ID 2X9M
Taxonomy ID 63330
Gene Starting Position 8679
Gene Ending Position 11242
Gene Strand (Orientation) +
Protein Name glycoprotein
Protein pI 7.51
Protein Weight 63419.1
Protein Length 604
DNA Sequence 
>NC_001906.3:8679-11242 Hendra virus, complete genome
TAGGACCCAAGTCCTTAACCACATTCTAATGTGAGGGAGAATTAAATGTACATTGAGACTGACAATCTAA
TATACAGAGTGTTTGATCAAGTTAAAACATCAATTGTCAGGAATTCATTGATAAACCAACTTGTTAGTTA
GAATTAAGAAAATATAAGAGCTAATACTCGCAAGTCATTTGCTTCTTCAAGAGCCTGTCTCAACTATCAA
GTGAATACATGATCTAAAACTAGTATGATGGCTGATTCCAAATTGGTAAGCCTGAACAATAATCTATCTG
GTAAAATCAAGGATCAAGGTAAAGTTATCAAGAATTATTACGGCACAATGGACATCAAGAAAATTAACGA
TGGGTTATTAGATAGTAAGATACTTGGGGCGTTTAACACAGTGATAGCTTTGTTGGGATCAATCATCATC
ATTGTGATGAATATCATGATAATTCAAAATTACACCAGAACGACTGATAATCAGGCACTAATCAAAGAGT
CACTCCAGAGTGTACAGCAACAAATCAAAGCTTTAACAGACAAAATCGGGACAGAGATAGGCCCCAAAGT
CTCACTAATTGACACATCCAGCACCATCACAATTCCTGCTAACATAGGGTTACTGGGATCCAAGATAAGT
CAGTCTACCAGCAGTATTAATGAGAATGTTAACGATAAATGCAAATTTACTCTTCCTCCTTTAAAGATTC
ATGAGTGTAATATCTCTTGTCCGAATCCTTTGCCTTTCAGAGAATACCGACCAATCTCACAAGGGGTGAG
TGATCTTGTAGGACTGCCGAACCAGATCTGTCTACAGAAGACAACATCAACAATCTTAAAGCCCAGGCTG
ATATCCTATACTCTACCAATTAATACCAGAGAAGGGGTTTGCATCACTGACCCACTTTTGGCTGTTGATA
ATGGCTTCTTCGCCTATAGCCATCTTGAAAAGATCGGATCATGTACTAGAGGAATTGCAAAACAAAGGAT
AATAGGGGTGGGTGAGGTATTGGATAGGGGTGATAAGGTGCCATCAATGTTTATGACCAATGTTTGGACA
CCACCCAATCCAAGCACCATCCATCATTGCAGCTCAACTTACCATGAAGATTTTTATTACACATTGTGCG
CAGTGTCCCATGTGGGAGATCCTATCCTTAACAGTACTTCCTGGACAGAGTCACTGTCTCTGATTCGTCT
TGCTGTAAGACCAAAAAGTGATAGTGGAGACTACAATCAGAAATACATCGCTATAACTAAAGTTGAAAGA
GGGAAGTACGATAAGGTGATGCCTTACGGTCCATCAGGTATCAAGCAAGGGGATACATTGTACTTTCCGG
CCGTCGGTTTTTTGCCAAGGACCGAATTTCAATATAATGACTCTAATTGTCCCATAATTCATTGCAAGTA
CAGCAAAGCAGAAAACTGTAGGCTTTCAATGGGTGTCAACTCCAAAAGTCATTATATTTTGAGATCAGGA
CTATTGAAGTATAATCTATCTCTTGGAGGAGACATCATACTCCAATTTATCGAGATTGCTGACAATAGAT
TGACCATCGGTTCTCCTAGTAAGATATACAATTCCCTAGGTCAACCCGTTTTCTACCAGGCATCATATTC
TTGGGATACGATGATTAAATTAGGCGATGTTGATACCGTTGACCCTCTAAGAGTACAGTGGAGAAATAAC
AGTGTGATTTCTAGACCTGGACAGTCACAGTGTCCTCGATTTAATGTCTGTCCCGAGGTATGCTGGGAAG
GGACATATAATGATGCTTTTCTAATAGACCGGCTAAACTGGGTTAGTGCTGGTGTTTATTTAAACAGTAA
CCAAACTGCAGAGAACCCTGTGTTTGCCGTATTCAAGGATAACGAGATCCTTTACCAAGTTCCACTGGCT
GAAGATGACACAAATGCACAAAAAACCATCACAGATTGCTTCTTGCTGGAGAATGTCATATGGTGTATAT
CACTAGTAGAAATATACGATACAGGAGACAGTGTGATAAGGCCAAAACTATTTGCAGTCAAGATACCTGC
CCAATGTTCAGAGAGTTGATTGACCAAAAGAGCAATAAATATTATATTATAATTATATCAGTCAAATTGT
AAACATCCTTCTTATAATATACTCAAAAAATTAAAAATTCCCCCAAGAAAATACTAAATGTAATCAAACT
CAATAAACCCTGAAATATTGATAGTTTACAGAGATCATATGACTCTTTGTATAATTCTTTATAGAACTCC
TAAATATCAAAGAGCGATAAACTTGCTACCCTGTACACTTAAAGCAGATACTGTGATTAACTCTGTAAGT
TTATCAGATAATCCTATTAGTGACATACTGAGGGTTATTCTTGTATAATTCTTCTGAAGATGTGATTACA
GATAATCTTTCAATCTAGTCAAGTAAGCCTGATTTCCTAATTATAATCTCCCTCTTAGGAGAAGGAGAAC
GTATCAATGTTCACTATATACTAAGTCTTTTATTTTAAATTTTTCTTATTGTCTTCAGATGAGCCTTATT
ACTTCATCTCATCAGATTATAAATTTTCTAATAAATTAAGAAAA
Protein Sequence 
>NP_047112.2 glycoprotein [Hendra henipavirus]
MMADSKLVSLNNNLSGKIKDQGKVIKNYYGTMDIKKINDGLLDSKILGAFNTVIALLGSIIIIVMNIMII
QNYTRTTDNQALIKESLQSVQQQIKALTDKIGTEIGPKVSLIDTSSTITIPANIGLLGSKISQSTSSINE
NVNDKCKFTLPPLKIHECNISCPNPLPFREYRPISQGVSDLVGLPNQICLQKTTSTILKPRLISYTLPIN
TREGVCITDPLLAVDNGFFAYSHLEKIGSCTRGIAKQRIIGVGEVLDRGDKVPSMFMTNVWTPPNPSTIH
HCSSTYHEDFYYTLCAVSHVGDPILNSTSWTESLSLIRLAVRPKSDSGDYNQKYIAITKVERGKYDKVMP
YGPSGIKQGDTLYFPAVGFLPRTEFQYNDSNCPIIHCKYSKAENCRLSMGVNSKSHYILRSGLLKYNLSL
GGDIILQFIEIADNRLTIGSPSKIYNSLGQPVFYQASYSWDTMIKLGDVDTVDPLRVQWRNNSVISRPGQ
SQCPRFNVCPEVCWEGTYNDAFLIDRLNWVSAGVYLNSNQTAENPVFAVFKDNEILYQVPLAEDDTNAQK
TITDCFLLENVIWCISLVEIYDTGDSVIRPKLFAVKIPAQCSES
Molecule Role Protective antigen
Molecule Role Annotation A subunit vaccine formulation containing only recombinant, soluble, attachment glycoprotein G from HeV (sG(HeV)) and CpG adjuvant was evaluated as a potential NiV vaccine in the cat model. Upon oronasal challenge with NiV (50,000TCID50), all vaccinated cats were protected from disease although virus was detected on day 21 post-challenge in one animal (McEachern et al., 2008).
Related Vaccines(s) Hendra virus G protein vaccine
References