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E2

Gene Name E2
Sequence Strain (Species/Organism) Western equine encephalomyelitis virus
VO ID VO_0011305
NCBI Protein GI 29611992
Other Database IDs CDD:279311
Taxonomy ID 11039
Gene Strand (Orientation) ?
Protein Name E2 protein
Protein pI 8.39
Protein Weight 44557.05
Protein Length 491
Protein Note Alphavirus E2 glycoprotein; pfam00943
Protein Sequence
>NP_818940.1 E2 protein [Western equine encephalitis virus]
SITDDFTLTSPYLGFCPYCRHSTPCFSPIKIENVWDESDDGSIRIQVSAQFGYNQAGTADVTKFRYMSFD
HDHDIKEDSMEKIAISTSGPCRRLGHKGYFLLAQCPPGDSVTVSITSGASENSCTVEKKIRRKFVGREEY
LFPPVHGKLVKCHVYDHLKETSAGYITMHRPGPHAYKSYLEEASGEVYIKPPSGKNVTYECKCGDYSTGI
VSTRTKMNGCTKAKQCIAYKSDQTKWVFNSPDLIRHTDHSVQGKLHIPFRLTPTVCPVPLAHTPTVTKWF
KGITLHLTAMRPTLLTTRKLGLRADATAEWITGSTSRNFSVGREGLEYVWGNHEPVRVWAQESAPGDPHG
WPHEIIIHYYHRHPVYTVIVLCGVALAILVGTASSAACIAKARRDCLTPYALAPNATVPTALAVLCCIRP
TNA

Molecule Role Protective antigen
Molecule Role Annotation This report describes the successful cloning of the E2 gene of WEEV and expression in Escherichia coli as inclusion bodies. The immunogenicity of the refolded rE2 protein was demonstrated by strong humoral and cell mediated immune (CMI) responses in rE2-immunized BALB/c mice. The current study also demonstrated that rE2-immunized mice could be partially protected from lethal challenge of WEEV (Das et al., 2007).
Additional Molecule Role Virmugen
Additional Molecule Role Annotation A PE2 mutant combined with a deletion in E2 (WE2102) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of this strain would occur (Turell et al., 2003).
Related Vaccines(s) WEEV Subunit E2 Protein Vaccine , Western equine encephalomyelitis virus PE2/E2 mutant virus
References