VIOLIN: Vaccine Investigation and Online Information Network

par1
Gene Name	par1
VO ID	VO_0011301
NCBI Protein GI	2209137
Other Database IDs	CDD:282940
Taxonomy ID	5693
Gene Strand (Orientation)	?
Protein Name	paraflagellar rod component
Protein pI	4.95
Protein Weight	64852.11
Protein Length	665
Protein Note	Paraflagellar rod protein; pfam05149
Protein Sequence	>AAC32021.1 paraflagellar rod component [Trypanosoma cruzi] MTVYHEQFALVPPQYPRRAVQEAENHRALAALYELVENAIATAENYVAYTEGRLVPLSSRGSELLAASKE LRERYRHEAPCGWTEQKVMQHCEQEVTVEEMAELLLRPPLDVAGIRSILRTLQETRTQLPRGRFLLMRDN LSALKPHQPPDLARDLSDVCGALYEIQYVDLMAELRAELSELDGERDKVQEKLKDAIHLYERAVAKGDVV EVERAHRQLIAARYEFVNACAKLMHQILGEDMASQESGFAAEMEALRRDAADSISRFAEALHERRQAFRN DLHNCDKKRLEEDGNHQKCLEVYNAEERETAAQIGQIVEQKKKLVEELRQKARELRDITLKQKEMVEAQV RAKRAEEERVTAYNEFVNMEEQQKHRLLRCLAYFDGMEELTADLRSYVDEMVTRIPQQNLRQVLDQLNDI EAEVFMNAYGGFVSCCGELTVKKMHRLDTLERQARLLEHNRDSAMESLDPNMSNYRLELDDIIEQMKGVS GVINALNATQDAGEQLFQSVEKGVLAKYERSGTPFVHPLQEYGIKSVEERNRFVDRSMHYVENEERKVLE KRNVLNRMRQAVEEDEAATESAIRNLNEEPAAPEY
Molecule Role	Protective antigen
Molecule Role Annotation	C57BL/6 mice were immunized s.c. with recombinant PFR-1 (PAR1) protein co-adsorbed to alum with rIL-12. rPFR-1 immunized animals were able to successfully resolve parasitemia by day 30 p.i., with the peak parasitemia occurring between days 17 and 21 p.i. (Luhrs et al., 2003).
Related Vaccines(s)	T. cruzi PAR1 Protein Vaccine
References