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CRP-10

Gene Name CRP-10
Sequence Strain (Species/Organism) Escherichia coli str. K-12 substr. MG1655
VO ID VO_0011297
NCBI Gene ID 947867
NCBI Protein GI 16131236
Locus Tag b3357
Genbank Accession U00096
Protein Accession NP_417816
Other Database IDs CDD:271234
CDD:290570
Taxonomy ID 511145
Gene Starting Position 3486119
Gene Ending Position 3486751
Gene Strand (Orientation) +
Protein Name DNA-binding transcriptional dual regulator CRP
Protein pI 8.46
Protein Weight 22251.2
Protein Length 210
Protein Note Also known as cap; csm; ECK3345; gurB
DNA Sequence
>NC_000913.3:3486119-3486751 Escherichia coli str. K-12 substr. MG1655, complete genome
CATGGTGCTTGGCAAACCGCAAACAGACCCGACTCTCGAATGGTTCTTGTCTCATTGCCACATTCATAAG
TACCCATCCAAGAGCACGCTTATTCACCAGGGTGAAAAAGCGGAAACGCTGTACTACATCGTTAAAGGCT
CTGTGGCAGTGCTGATCAAAGACGAAGAGGGTAAAGAAATGATCCTCTCCTATCTGAATCAGGGTGATTT
TATTGGCGAACTGGGCCTGTTTGAAGAGGGCCAGGAACGTAGCGCATGGGTACGTGCGAAAACCGCCTGT
GAAGTGGCTGAAATTTCGTACAAAAAATTTCGCCAATTGATTCAGGTAAACCCGGACATTCTGATGCGTT
TGTCTGCACAGATGGCGCGTCGTCTGCAAGTCACTTCAGAGAAAGTGGGCAACCTGGCGTTCCTCGACGT
GACGGGCCGCATTGCACAGACTCTGCTGAATCTGGCAAAACAACCAGACGCTATGACTCACCCGGACGGT
ATGCAAATCAAAATTACCCGTCAGGAAATTGGTCAGATTGTCGGCTGTTCTCGTGAAACCGTGGGACGCA
TTCTGAAGATGCTGGAAGATCAGAACCTGATCTCCGCACACGGTAAAACCATCGTCGTTTACGGCACTCG
TTA
Protein Sequence
>NP_417816.1 DNA-binding transcriptional dual regulator CRP [Escherichia coli str. K-12 substr. MG1655]
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDF
IGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDV
TGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR
Molecule Role Protective antigen
Molecule Role Annotation A complement regulatory protein (CRP) of Trypanosoma cruzi was evaluated as a vaccine candidate in a murine model of experimental T. cruzi infection. Recombinant CRP derived from an Escherichia coli expression system and a plasmid encoding the full-length crp structural gene under the control of a eukaryotic promoter were used to immunize BALB/c mice. Immunization with both protein and DNA vaccines resulted in a Th1-type T-cell response, comparable antibody titers, and similar immunoglobulin G isotype profiles. Only mice immunized with the crp DNA plasmid produced antibodies capable of lysing the parasites in the presence of complement and were protected against a lethal challenge with T. cruzi trypomastigotes (Sepulveda et al., 2000).
Related Vaccines(s) T. cruzi DNA Vaccine encoding CRP-10 Protein
References