VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Cov19VaxKB
Host Responses
VaximmutorDB
VIGET
Vaxafe
Vaxar
Vaxism
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign2
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UM Logo

CP cysteine proteinase

Gene Name CP cysteine proteinase
Sequence Strain (Species/Organism) Leishmania amazonensis
VO ID VO_0011295
NCBI Nucleotide GI 30142041
NCBI Protein GI 30142042
Protein Accession AAN34826.1
Other Database IDs CDD:185513
CDD:214853
CDD:278538
CDD:239068
Taxonomy ID 5659
Gene Strand (Orientation) ?
Protein Name cysteine proteinase
Protein pI 6.56
Protein Weight 36075.3
Protein Length 418
Protein Note forma: amastigote
DNA Sequence 
>gi|30142041|gb|AY141759.1| Leishmania mexicana amazonensis clone 2A1 cysteine proteinase mRNA, complete cds
CCGTCACGCCCTTCTCGTGCGCACGTTGCAGAACCAGGATCGGCAAAGATGGCGCGCCGCAACCCCCTTT
TGTTTGCGATAGTGGTGACGATCCTGTTCGTGGTGTGCTACGGTTCCGCTCTCATCGCCCAGACACCCCC
CGCCGTCGACAACTTCGTTGCCTCAGCGCATTACGGAAGTTTTAAGAAGCGCCACAGTAAGGCCTTCGGC
GGGGACGCCGAGGAGGGTCACCGCTTCAATGCCTTCAAGCAGAACATGCAGACAGCCTACTTCCTCAACA
CGCAGAACCCCCACGCGCACTACGACGTGTCCGGCAAGTTCGCGGACCTCACCCCGCAGGAGTTCGCCAA
GCTGTACCTGAATCCCGACTACTACACGAGCCACCTCAAGGATCACAAGGAGGACGTGCACGTCGACGAC
AGCGCCCCCAGTGGTGTGATGTCGGTGGACTGGCGTGATAAGGGTGCCGTGACGCCGGTGAAGAACCAGG
GATTATGCGGCTCGTGCTGGGCCTTCTCCGCCATTGGCAACATCGAAGGTCAGTGGGCTGCAAGCGGCCA
CTCGTTGGTTTCACTGTCAGAACAGATGCTCGTGTCGTGCGACAACGTCGATGAAGGGTGCAACGGCGGG
CTGATGGACCAGGCAATGAACTGGATCATGCAGAGTCACAACGGCAGTGTGTTCACGGAGGCCAGCTATC
CCTACACCTCTGGCGGCGGCACCAGACCGCCGTGCCATGACGAAGGTGAAGTTGGCGCTAAAATCACCGG
TTTCCTCTCCCTGCCGCACGACGAGGAGCGGATCGCGGACTGGGTGGAGAAGAGAGGCCCCGTCGCCGTC
GCCGTCGACGCGACAACCTGGCAGCTGTACTTTGGCGGTGTGGTCTCCCTCTGCCTCGCGTGGTCGCTCA
ACCACGGTGTGCTCATTGTCGGCTTCAACAAAAACGCGAAACCGCCGTACTGGATCGTGAAGAACTCGTG
GGGCTCCTCGTGGGGTGAGAAGGGGTACATCCGCCTTGCCATGGGCAGCAACCAGTGCATGCTCAAGAAT
TACCCCGTGTCGGCCACGGTTGAAAGCCCCCACACCCCACACGTGCCGACGACAACGGCCTAGCTGGAGC
CCAGGCCCACGGCGCCTGGGCGAATGAGCTGCTTTTTTTTTCGAGTGGGTGCTCGAGGCTGTGCACAAGC
ACGACCTATCCGACCTGTGTGTGCCTGAAGCGCCAGAATGGCGGCTCTGCCCAGGTGACCTGTGGCAAAC
CCGAGACGGCGGAGCTTCTCTACAACTGGCCGGGTTGCTCCGAGGCTGCCACCGAGGCCTGCATGCCGCT
GAACAATATGTATGCGCAGCTACGCCGGCTACCTCCAGAACGTCTGCACTGCGTTCGTCGCTTGCACTGA
GAACCAACGACGCCGTCTCTGACTTGACCAAGCCAACCATCTTGGGCCAACCACACGTCCCGTACGCGAG
GCACGCGGGGATCCAGGACTGGCAGGATCCACTGCGCACTATACGCCTCAGCTGCACCGATGCGGATCCC
TCCCTCAAAAAAAAAAAAAAAAAAAAAA
Protein Sequence 
>AAN34826.1 cysteine proteinase [Leishmania amazonensis]
MARRNPLLFAIVVTILFVVCYGSALIAQTPPAVDNFVASAHYGSFKKRHSKAFGGDAEEGHRFNAFKQNM
QTAYFLNTQNPHAHYDVSGKFADLTPQEFAKLYLNPDYYTSHLKDHKEDVHVDDSAPSGVMSVDWRDKGA
VTPVKNQGLCGSCWAFSAIGNIEGQWAASGHSLVSLSEQMLVSCDNVDEGCNGGLMDQAMNWIMQSHNGS
VFTEASYPYTSGGGTRPPCHDEGEVGAKITGFLSLPHDEERIADWVEKRGPVAVAVDATTWQLYFGGVVS
LCLAWSLNHGVLIVGFNKNAKPPYWIVKNSWGSSWGEKGYIRLAMGSNQCMLKNYPVSATVESPHTPHVP
TTTA
Molecule Role Protective antigen
Molecule Role Annotation A 500 bp fragment encoding an isoform of cysteine proteinase (CP) from Leishmania (Leishmania) amazonensis was subcloned and expressed in the pHis vector, resulting in a recombinant protein of 24 kDa, rLacys24. Immunization of BALB/c mice with rLacys24 plus CFA adjuvant resulted in a low but significant decrease of foot lesions after challenge with L. (L.) amazonensis compared to those exhibited by control mice (Fedeli et al., 2010).
Related Vaccines(s) L. amazonensis CP Protein Vaccine
References