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WD

Gene Name WD
Sequence Strain (Species/Organism) Leishmania amazonensis
VO ID VO_0011290
NCBI Nucleotide GI 38455440
NCBI Protein GI 38455441
Protein Accession AAR20840.1
Other Database IDs CDD:225201
CDD:238121
CDD:293791
Taxonomy ID 5659
Gene Strand (Orientation) ?
Protein Name antigenic WD protein
Protein pI 6.52
Protein Weight 70626.83
Protein Length 743
Protein Note WD40 repeat [General function prediction only]; COG2319
DNA Sequence 
>gi|38455440|gb|AY457171.1| Leishmania amazonensis antigenic WD protein mRNA, complete cds
CCCTCCCACTACCACGCAGCTTGTCATATCATACTGTGTTTCATTGTATGCATCCGGCGTGAGCAATTCT
TTGTGTCCTCAACCGCTCTTTCCTTTCGTCTTTCATCGCTGTGCTTCCTCTCCCCTCAGCGCCCCCCCCT
CTCCCTTCTCGCACACGCACGCACAGTGGCACAGATACATACAGAGGCACTCCTCTTCTCCCTACACTAT
CTTGCAGTGCCCTCTTCTTCCCCCGCCTCTTACTCTGCCCGTCCCTCTCCGACTCTCTTTCACGTTTCGC
AACACCAGTATCAACCATGGCCAAGGAGAAACTCGGCTTCAAGATCCAGGGGAAGACCGTCTCCTACGAG
GGTTACCCCGAGCGTCCGCCAAGGGACCTGATGGACATCTTGGTCAAAATGGGTGTCGGCGAAGCTGCCG
TGGTGACCACCTTTCTAGAAAATATTGAGAACCACCGGGAGTTCACCGACGAGCAGGTGATGGTGATGTA
CAACGAAGCAAAAATGACGCGCGAGAAGAAGGCTCGTGCGAAGGCCGGCAACCAGGGTGACTCAGCCGCT
GCCGCCGCCGCTCCATCGGGCGCCGCCGATGAGGCGGAGAAGCCGCAGAAGATCCTTCTTTCCTACCGCG
GCAAGCAGCTTTCCTACGTAGGTTTGCCCAGCGGCAAGCGCAACGCCGTGCTGCAACTCCTCTCCAAGCA
AGAGGAGCTCACCCGGGAGCTTGCAGTGGAGACGTTCCGCACGAACCTGCCCAGTGATCCGTCCACGGAG
GAGGAGATTTGGATCTTGGTGCAGGCAGTCAAAGATCGCAAGAGTAGGAAGAGCCAAGCGAAGGGTCAGG
ATGGCGAAAGGTCCGGCGGTAACGGTGCGACTGCGTCGCTTGGGGCAGGCAGCAGCGCCATGGACAGCAT
AACCGGTATGTCCGAGAGGGAGCGCGACGACCTGAACAACTTCATTCTTCAGGTGCTGCAGCAGCCAGCG
CCGGATGTGGCCGCCCTCTTACATGAGAATCCGAAACCGCGCAAAGACACGGAAGACAATGCGGAGCTGG
CACTGACAGCGCGCATGTCGGGTAAGATTCCGGTTTACCTGCAGGAAGAGAACACCAGCAGCACGAAGCT
CATCTACGCCACGCCCCACATGAGCTTCGAAGATTTTTCTACCATTGTCGAGAAGAAGTGTGGCCGCAAG
TTGTCGCTGTCCTTCTACGACGGCGACGACCTCATCATGATGGATGATGACGACGTGCTGGCCATGTTTC
TCGAAATGACAGTGCAGAACGACCCAAAGAAGGTGCGCCTCATTTGCTCCAACCCTGGAGTCCCAAGGAA
GGCGGCGGATGACCGGATGATGGAAAACCGTCAAAATACCTTCAGCGGTCTTCCGCAGGTCTCAACGACC
AAGGCATTGGCGTACTCGAACGGCGAGCTCAACGTCGCGGAGGCTCGCACCTACTTTGGCCACTCTCTTG
CCGTCTACTGCTGCTGCTTCTCGCCAAGGGGCGACATGTTCGTTACGGCAAGTCGCGACCGCACCGTCCG
CCTGTGGAACTTGCGCACCGGTGTCTCCACAGTCATGAAAGGCGGGCACAACGGCTTTGTGCTGTCTTGC
GACTACTCGCCAAAGGGCAACCGCGTCGCTTCCTCTTCTGATGACCGCACTATCAAACTGTGGAACACGT
CGTCATGCAACAAGGTTGCCACACTTAAAGGGCACGAGGACAAGGTATACTGCGTCAAGTACAACTCTAG
CGGAGATCTCCTCGTGTCCGCCTCTTGCGACACCACAGTGCGCGTGTGGAACGCCGAAAGTCAGGCGAAG
CTGGTGACGCTGAGGGGCCACACCCTCGCCGTTTTTTCCTGCGCCTTCAGCAACAGCGATAATGGAAAGT
TCGTCGTCTCCGGCAGCGATGACCGCGTTATAAAGCTGTGGGACTGGGGCGCCGGCAGAGAGATCCTGTC
GCTGGTGGGTCACATCGGCACCGTGTGGACGGTTGTCTTCTCCCACAACGACAGGTACGTTCTCAGTGGC
AGCATGGACTATGAGCTCATTCTCTGGGATTCAATGACTGGCGCTCGCCTGCGCTCGATGGACGGGCACA
AGACATCGGTGCACCACGCCATCTTCTCCGAGGACGACGCATACATCTTCTCCTGCGCCCGCGACTGGAG
CGTCATGGTGTGGCGCACCGAAGATGGCGAGCATGTAGAGACCATCATCGGTCACCTCAGCACTGTCTAC
CACATGGACATCAGCGAGGACAAGTTGCTCACCTGCTCTCTTGATGACAAGATCAAGCTGTGGAATATCA
GGCGCCACTGAAGTTGAGCACCAGCGGAAAATGTGGTAGTGCGAACACTGGCGGGAGGGGCACGTGCCAG
CCGCAACCGAGAAAGAGGTGTGGGCGGGAAGGCACGTGATAGGTGATACAGACACTGTACCCGTACACCA
TTCCTCTTTTCAGCAGCAGTCCTGCACACAGAAAGACACTCGGATTTTTCATTGACAAATCAGGTGGGTC
TGAAGACGATTTCAAGAAGAAGCGAGCGTTCGTATGTACCGCCCTCCTCCCTCCACCGATACTGCAACAC
ACACACACACACATTTTACGGTCTTGTCTACTTTTCTTCGTTTCGCTCTCGTCAGTTCCACCGAGTCCTG
GCTGCGTTTGGGTGCCACGCGTGTGAATGTGTGAGCGCCACCGTTGGTCGACCCTTTTCGCTTTCCTGCA
TGCTTTTTTTCTTTTCGTATCTCTACGTCCTGCTCACAGCGCATCGACCTCTGCCAGAGGATATCATTTG
GCAGTGTCGTTTCTTTTGCTCTTTTTCTCTCTTTGCCACCGTTCTTGCGGGCCAACGGCACCGTGCTCCC
CGCTTCTCTGTCTCGCGACCTCGACATTCATCTCTTCCATGCTTCTCCCTCTCCCCCTCCGTCTCCCCAG
CTTTTTGTCGTTTGTGCATTCTCCTCTTTTCTTAAGTGATGCTTCAAAGGAAACGAAAAAAAAAAAAAAA
AA
Protein Sequence 
>AAR20840.1 antigenic WD protein [Leishmania amazonensis]
MAKEKLGFKIQGKTVSYEGYPERPPRDLMDILVKMGVGEAAVVTTFLENIENHREFTDEQVMVMYNEAKM
TREKKARAKAGNQGDSAAAAAAPSGAADEAEKPQKILLSYRGKQLSYVGLPSGKRNAVLQLLSKQEELTR
ELAVETFRTNLPSDPSTEEEIWILVQAVKDRKSRKSQAKGQDGERSGGNGATASLGAGSSAMDSITGMSE
RERDDLNNFILQVLQQPAPDVAALLHENPKPRKDTEDNAELALTARMSGKIPVYLQEENTSSTKLIYATP
HMSFEDFSTIVEKKCGRKLSLSFYDGDDLIMMDDDDVLAMFLEMTVQNDPKKVRLICSNPGVPRKAADDR
MMENRQNTFSGLPQVSTTKALAYSNGELNVAEARTYFGHSLAVYCCCFSPRGDMFVTASRDRTVRLWNLR
TGVSTVMKGGHNGFVLSCDYSPKGNRVASSSDDRTIKLWNTSSCNKVATLKGHEDKVYCVKYNSSGDLLV
SASCDTTVRVWNAESQAKLVTLRGHTLAVFSCAFSNSDNGKFVVSGSDDRVIKLWDWGAGREILSLVGHI
GTVWTVVFSHNDRYVLSGSMDYELILWDSMTGARLRSMDGHKTSVHHAIFSEDDAYIFSCARDWSVMVWR
TEDGEHVETIIGHLSTVYHMDISEDKLLTCSLDDKIKLWNIRRH
Molecule Role Protective antigen
Molecule Role Annotation DNA vaccination in BALB/c mice with the LAWD (for Leishmania antigenic WD protein) and IL-12 genes significantly delayed lesion development from challenge with Leishmania amazonensis, which correlated with a dramatic reduction in parasite burdens (Campbell et al., 2004).
Related Vaccines(s) L. amazonensis DNA vaccine encoding WD protein
References