VIOLIN: Vaccine Investigation and Online Information Network

amastigote surface protein-2
Gene Name	amastigote surface protein-2
VO ID	VO_0011289
NCBI Gene ID	3537357
NCBI Protein GI	284180153
Other Database IDs	CDD:240366 CDD:271234
Taxonomy ID	5693
Gene Strand (Orientation)	?
Protein Name	amastigote surface protein-2
Protein pI	6.84
Protein Weight	70196.77
Protein Length	785
Protein Note	ASP-2
Protein Sequence	>ADB82626.1 amastigote surface protein-2, partial [Trypanosoma cruzi] MLSRVAAVKAPRTHNRHRVTGSSGRRREGRESEPQRPDMSWRAFTSAVLLLLLVIICCGSGAADAVEGKS GAVQLPKWVDIFVPEKTHVLPKEGSESGVKKAFAAPSLVSAGGVMVAFAEGLFGHNVHGYDLFGIRPYEI LAGYIKAAESWPSIVAEVNASTWRAHTVIGSRNGNDRLCFLYRPTAVARENKVFLLVGSDTVGYDSDDDM WVKDGWDIQLVEGVATQSTDGKPSKTINWGEPKSLLKQVPKHTQDQLRDVVTAGGSGIVMQNNTFVFPLV VNGKNYPFSSITYSTDNGNNWVFPESISPVGCLDPRITEWETGQILMIVDCGNGQSVYESRDMGKTWTEA IGTLSGVWVKSRSGFRWDEGLRVDALITATIEGRKVMLYTQRGCASGEKEANALYLWVTDNNRTFHVGPV AMDSAVNETLSNALLYSDGNLHLLKQRANEKGSALSLARLTEELKEIDSVLSTWARLDASFSASSTPTAG LVGFLSNTSSGGDTWNDEYRCVDASVTKASKVKNGIKFTGPGSMATWLVNSREDNRQYGFVNHSFTLVAT VTIHQVAKGSTPLLGAGLDAPVSTNFIGLSYSMDKRWETVFYGKKTTSNTTWELGKEYQVALMLQDGNKG SVYVDGVIVGSPENITKLGALGHEIAHFYFGGDEGYINSSVTVTNVFLYNRPLSVGELKMVRKSDDKKGN GGD
Molecule Role	Protective antigen
Molecule Role Annotation	To examine the efficacy of a new mode of recombinant viral vaccine, a vaccine was constructed of two non-transmissible Sendai viruses (rSeV/dF) encoding the full-length parasite antigen amastigote surface protein-2 (ASP2) or ASP2 fused with a mono-ubiquitin on its N-terminus (UASP2). C57BL/6 mice immunized intranasally with rSeV/dF expressing either ASP2 or UASP2 showed significantly suppressed parasitemia and could be protected from lethal T. cruzi challenge (Duan et al., 2009).
Related Vaccines(s)	T. cruzi DNA vaccine encoding ASP-2 , T. cruzi DNA vaccine encoding TSA-1, ASP-1, ASP-2 , T. cruzi DNA vaccine pUB-ASP-2 , T. cruzi Vaccine encoding ASP2 with Rapamycin , T. cruzi vaccine using Sendai virus vector expressing amastigote surface protein-2
References

amastigote surface protein-2