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amastigote surface protein-2

Gene Name amastigote surface protein-2
VO ID VO_0011289
NCBI Gene ID 3537357
NCBI Protein GI 284180153
Other Database IDs CDD:240366
CDD:271234
Taxonomy ID 5693
Gene Strand (Orientation) ?
Protein Name amastigote surface protein-2
Protein pI 6.84
Protein Weight 70196.77
Protein Length 785
Protein Note ASP-2
Protein Sequence
>ADB82626.1 amastigote surface protein-2, partial [Trypanosoma cruzi]
MLSRVAAVKAPRTHNRHRVTGSSGRRREGRESEPQRPDMSWRAFTSAVLLLLLVIICCGSGAADAVEGKS
GAVQLPKWVDIFVPEKTHVLPKEGSESGVKKAFAAPSLVSAGGVMVAFAEGLFGHNVHGYDLFGIRPYEI
LAGYIKAAESWPSIVAEVNASTWRAHTVIGSRNGNDRLCFLYRPTAVARENKVFLLVGSDTVGYDSDDDM
WVKDGWDIQLVEGVATQSTDGKPSKTINWGEPKSLLKQVPKHTQDQLRDVVTAGGSGIVMQNNTFVFPLV
VNGKNYPFSSITYSTDNGNNWVFPESISPVGCLDPRITEWETGQILMIVDCGNGQSVYESRDMGKTWTEA
IGTLSGVWVKSRSGFRWDEGLRVDALITATIEGRKVMLYTQRGCASGEKEANALYLWVTDNNRTFHVGPV
AMDSAVNETLSNALLYSDGNLHLLKQRANEKGSALSLARLTEELKEIDSVLSTWARLDASFSASSTPTAG
LVGFLSNTSSGGDTWNDEYRCVDASVTKASKVKNGIKFTGPGSMATWLVNSREDNRQYGFVNHSFTLVAT
VTIHQVAKGSTPLLGAGLDAPVSTNFIGLSYSMDKRWETVFYGKKTTSNTTWELGKEYQVALMLQDGNKG
SVYVDGVIVGSPENITKLGALGHEIAHFYFGGDEGYINSSVTVTNVFLYNRPLSVGELKMVRKSDDKKGN
GGD
Molecule Role Protective antigen
Molecule Role Annotation To examine the efficacy of a new mode of recombinant viral vaccine, a vaccine was constructed of two non-transmissible Sendai viruses (rSeV/dF) encoding the full-length parasite antigen amastigote surface protein-2 (ASP2) or ASP2 fused with a mono-ubiquitin on its N-terminus (UASP2). C57BL/6 mice immunized intranasally with rSeV/dF expressing either ASP2 or UASP2 showed significantly suppressed parasitemia and could be protected from lethal T. cruzi challenge (Duan et al., 2009).
Related Vaccines(s) T. cruzi DNA vaccine encoding ASP-2 , T. cruzi DNA vaccine encoding TSA-1, ASP-1, ASP-2 , T. cruzi DNA vaccine pUB-ASP-2 , T. cruzi Vaccine encoding ASP2 with Rapamycin , T. cruzi vaccine using Sendai virus vector expressing amastigote surface protein-2
References