VIOLIN: Vaccine Investigation and Online Information Network

tox
Gene Name	tox
Sequence Strain (Species/Organism)	Corynebacterium diphtheriae
VO ID	VO_0011287
NCBI Protein GI	38199106
Other Database IDs	CDD:280859 CDD:238651 CDD:280860 CDD:279642 GOA:Q6NK15 InterPro: IPR000512 InterPro: IPR022404 InterPro: IPR022405 InterPro: IPR022406 UniProtKB/TrEMBL: Q6NK15
Taxonomy ID	1717
Gene Strand (Orientation)	?
Protein Name	Diphtheria toxin precursor
Protein pI	6.37
Protein Weight	56772.07
Protein Length	638
Protein Note	biotype gravis
Protein Sequence	>CAE48728.1 Diphtheria toxin precursor [Corynebacterium diphtheriae] MSRKLFASILIGALLGIGAPPSAHAGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGN YDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLM EQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQA CAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTAL EHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNT EEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYA VSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAID GDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKS
Molecule Role	Protective antigen
Molecule Role Annotation	In 1923, it was discovered that treatment with formalin eliminated the toxicity of diphtheria toxin (DT) without destroying its immunogenicity. Formalin‐treated DT, now called diphtheria toxoid, rapidly became the preferred vaccine against diphtheria, and diphtheria toxoid (usually in combined vaccines, such as diphtheria‐tetanus toxoids–pertussis vaccine [DTP] or diphtheria‐tetanus toxoids–acellular pertussis vaccine [DTaP] for children and tetanus‐diphtheria toxoids vaccine for adults [Td]) is still used throughout the world for active immunization against diphtheria (Holmes, 2000).
References

tox