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HASPB1

Gene Name HASPB1
Sequence Strain (Species/Organism) Leishmania infantum
VO ID VO_0011286
NCBI Gene ID 5069221
NCBI Nucleotide GI 3724133
NCBI Protein GI 3724134
Protein Accession CAA09789.1
Other Database IDs CDD:273344
UniProtKB/TrEMBL: O77301
Taxonomy ID 5661
Gene Strand (Orientation) ?
Protein Name HASPB1 protein
Protein pI 4.47
Protein Weight 42746.61
Protein Length 457
Protein Note K+-dependent Na+/Ca+ exchanger; TIGR00927
DNA Sequence 
>gi|3724133|emb|AJ011810.1| Leishmania donovani HASPB1 gene
ATGGGAACTTCTTGTACAAAGGACTCCGCAAAGGAGCCCCAGAAGCGTGCTGATAACATCCATAAAACCA
CTGAGGCCAATCACGGAGGCGCCACTGGTGTGCCCCCGAAGCACACCGGCAGTGCGATGAACGACTCTGC
CCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAA
AATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACG
GCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGG
CCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAA
AATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACG
GCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGG
CCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAA
AATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACG
GCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGG
CCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAA
AATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACG
GCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGG
CCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAA
AATGACGGCGATGGCCCTAAGGAGGGTGAGAATCTGCAGCAAAACGATGGGGATGCGCAGGAGAAGAACG
AAGATGGACACAACGTGGGGGATGGAGCTAACGGCAATGAGGATGGTAACGATGATCAGCCGAAGGAGCA
CGCTGCCGGCAACTAG
Protein Sequence 
>CAA09789.1 HASPB1 protein [Leishmania donovani]
MGTSCTKDSAKEPQKRADNIHKTTEANHGGATGVPPKHTGSAMNDSAPKEDGHTQKNDGDGPKEDGHTQK
NDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQK
NDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQK
NDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQK
NDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQK
NDGDGPKEGENLQQNDGDAQEKNEDGHNVGDGANGNEDGNDDQPKEHAAGN
Molecule Role Protective antigen
Molecule Role Annotation Following infection with L. infantum promastigotes, four out of eight beagle dogs immunized with HASPB1 Montanide remained free of clinical signs, compared to two out of eight dogs in the control group. The results demonstrate that HASPB1 antigens with Montanide were able to induce partial protection against canine leishmaniasis, even under extreme experimental challenge conditions (Moreno et al., 2007).
Related Vaccines(s) L. infantum HASPB1 protein vaccine
References