VIOLIN: Vaccine Investigation and Online Information Network

Gp63
Gene Name	Gp63
Sequence Strain (Species/Organism)	Leishmania major
VO ID	VO_0011278
NCBI Gene ID	5649645
NCBI Protein GI	259011719
3D structure: PDB ID	1LML
Other Database IDs	CDD:279761
Taxonomy ID	5664
Gene Strand (Orientation)	?
Protein Name	GP63
Protein pI	6.66
Protein Weight	58512.43
Protein Length	648
Protein Note	Leishmanolysin; pfam01457
Protein Sequence	>ACL01096.2 GP63 [Leishmania major] MSVDSSSTHRRRCVAARLVRLAAAGAAVTVAVGTAAAWAHAGALQHRCVHDAMQARVRQSVADHHKAPGA VSAVGLPYVTLDAAHTAAAADPRPGSARSVVRDVNWGALRIAVSTEDLTDPAYHCARVGQHVKDHAGAIA ICTAEDILTNEKRDILVKHLIPQAVQLHTERLKVQQVQGKWKVTDMVGDICGDFKVPQAHITEGFSNTDF VMYVASVPSEEGVLAWATTCQTFSDGHPAVGVINIPAANIASRYDQLVTRVVTHEMAHALGFSGPFFEDA RIVASVPNVRGKNFDVPVINSSTAVAKAREQYGCDTLEYLEVEDQGGAGSAGSHIKMRNAQDELMAPAAA AGYYTALTMAIFQDLGFYQADFSKAEVMPWGQNAGCAFLTNKCMEQSVTQWPAMFCNESEDAIRCPTSRL SLGACGVTRHPGLPPYWQYFTDPSLAGVSAFMDYCPVVVPYSDGSCTQRASEAHASLLPFNVFSDAARCI DGAFRPKATDGIVKSYAGLCANVQCDTATRTYSVQVHGSNDYTNCTPGLRVELSTVSNAFEGGGYITCPP YVEVCQGNVQAAKDGGNTAAGRRGPRAAATALLVAALLAVAL
Molecule Role	Protective antigen
Molecule Role Annotation	Cell-mediated immunity to Leishmania major (L. major) was induced by injecting BALB/c mice intradermally with plasmid DNA expressing the conserved L. major cell surface glycoprotein gp63 (gp63-pcDNA-3). Challenge studies revealed that gp63-pcDNA-3 vaccination protected 30% of susceptible mice (21 of 70) from Leishmania infection (Walker et al., 1998).
Related Vaccines(s)	L. major DNA Vaccine encoding Gp63
References