VIOLIN: Vaccine Investigation and Online Information Network

Cpa
Gene Name	Cpa
Sequence Strain (Species/Organism)	Leishmania major
VO ID	VO_0011275
NCBI Gene ID	5651252
NCBI Nucleotide GI	71084305
NCBI Protein GI	71084306
Protein Accession	AAZ23598.1
Other Database IDs	CDD:185513 CDD:285458 CDD:278538 CDD:239068
Taxonomy ID	5664
Gene Strand (Orientation)	?
Protein Name	cysteine protease
Protein pI	6.62
Protein Weight	33970.17
Protein Length	391
Protein Note	cathepsin L protease; Provisional
DNA Sequence	>gi\|71084305\|gb\|DQ071680.1\| Leishmania major cysteine protease (Cpa) gene, partial cds AAAACACCTCTCGGTGTCGACAACTTCATTGCCTCAGCACATTACGGACGCTTTAAGGAGCGCCACGGCA AGTCCTTCGGCGAGGACGCCGATGAGGGTCACCGCTTCAATGCCTTCAAGCAGAACATGCAGACCGCCTA CTTCCTCAACACGCACAACCCGCACGCGCACTACGACGTGTCCGGCAAGTTTGCAGACCTCACCCCCCAG GAGTTCGCCAAGCTGTACCTGAACCCCGACTACTACGCGCGCCGCGGTAAGGATTACAAGGAGCACGTGC ACGTCGACGACAGCGTCCTCAGTGGTGCGATGTCGGTGGACTGGCGTGAGAAGGTTGCCGTGACGCCGGT GAAGAACCAGGGAATGTGCGGCTCGTGCTGGGCTTTCTCCGCCATTGGCAACATTGAAAGTCAGTGGGCT TTGAAAAACCACTCGCTGGTTTCGCTGTCGGAGCAGATGCTCGTGTCATGCGACGACATCGATGATGGGT GCAACGGTGGGCTGATGGACCAGGCGATGGAATGGATCATCCAACATCACAACGGCACTGTGCCCACGGA GGAAAGCTACCCCTACGCCTCTGCCGGCGGCACGAGCCCGCCGTGCCATGACAAAGGCGAGTTTGGCGCC AGAATCAGTGGTTACATGTCCCTGCCGCATGACGAGAAGGCGATCGCGGCTTATGTGGAGAAGAAAGGCC CCGTCGCTGTCGCCGTCGACGCGACAACCTGGCAGCTGTACTTTGGCGGTGTGGTCACGCTCTGCTTCGG GTGGTCGCTCAACCACGGTGTGCTCGTTGTCGGCTTCAACAAAAGAGCGAAACCGCCGTACTGGATCGTG AAGAACTCGTGGGGCACCTCGTGGGGTGAGAAGGGGTACATCCGCCTTGCCATGGGCAGCAACCAGTGCT TGCTGAAGAATTACCCTGTGACGGCCACGGTTGACGACTCAAACACCTCTCCCGTGCCGACGACACCGGC CTAG
Protein Sequence	>AAZ23598.1 cysteine protease, partial [Leishmania major] KTPLGVDNFIASAHYGRFKERHGKSFGEDADEGHRFNAFKQNMQTAYFLNTHNPHAHYDVSGKFADLTPQ EFAKLYLNPDYYARRGKDYKEHVHVDDSVLSGAMSVDWREKVAVTPVKNQGMCGSCWAFSAIGNIESQWA LKNHSLVSLSEQMLVSCDDIDDGCNGGLMDQAMEWIIQHHNGTVPTEESYPYASAGGTSPPCHDKGEFGA RISGYMSLPHDEKAIAAYVEKKGPVAVAVDATTWQLYFGGVVTLCFGWSLNHGVLVVGFNKRAKPPYWIV KNSWGTSWGEKGYIRLAMGSNQCLLKNYPVTATVDDSNTSPVPTTPA
Molecule Role	Protective antigen
Molecule Role Annotation	Researchers evaluated the potency of different DNA vaccine candidates in BALB/c mice using high dose footpad parasite challenge with L. major. Mice inoculated pCMV3ISS-CPa developed significantly smaller lesions in their footpads after challenge with the parasite. The vaccine was able to induce a partially protective effect (Ahmed et al., 2009).
Related Vaccines(s)	L. major DNA Vaccine encoding LACKp24, TSA, LmSTI1 and CPa
References

Cpa