VIOLIN: Vaccine Investigation and Online Information Network

TSA
Gene Name	TSA
Sequence Strain (Species/Organism)	Leishmania major
VO ID	VO_0011273
NCBI Nucleotide GI	3411093
NCBI Protein GI	3411094
Protein Accession	AAC31146.1
Other Database IDs	CDD:140280 CDD:239313
Taxonomy ID	5664
Gene Strand (Orientation)	?
Protein Name	thiol specific antioxidant
Protein pI	6.75
Protein Weight	20885.27
Protein Length	261
Protein Note	tryparedoxin peroxidase; Provisional
DNA Sequence	>gi\|3411093\|gb\|AF044679.1\| Leishmania major thiol specific antioxidant (TSA) mRNA, complete cds CTGTACTTTATTGCCACCAGCCAGCCATGTCCTGCGGTAACGCCAAGATCAACTCTCCCGCGCCGTCCTT CGAGGAGGTGGCGCTCATGCCCAACGGCAGCTTCAAGAAGATCAGCCTCTCCTCCTACAAGGGCAAGTGG GTCGTGCTCTTCTTCTACCCGCTCGACTTTAGCTTCGTGTGCCCGACAGAGGTCATCGCGTTCTCCGACA GCGTGAGTCGCTTCAACGAGCTCAACTGCGAGGTCCTCGCGTGCTCGATAGACAGCGAGTACGCGCACCT GCAGTGGACGCTGCAGGACCGCAAGAAGGGCGGCCTCGGGACCATGGCGATCCCAATGCTAGCCGACAAG ACCAAGAGCATCGCTCGTTCCTACGGCGTGCTGGAGGAGAGCCAGGGCGTGGCCTACCGCGGTCTCTTCA TCATCGACCCCCATGGCATGCTGCGTCAGATCACCGTCAATGACATGCCGGTGGGCCGCAGCGTGGAGGA GGTTCTACGCCTGCTGGAGGCTTTTCAGTTCGTGGAGAAGCACGGCGAGGTGTGCCCCGCGAACTGGAAG AAGGGCGCCCCCACGATGAAGCCGGAACCGAATGCGTCTGTCGAAGGATACTTCAGCAAGCAGTAAACCT GTGAGCGTCGCAGGAGTCAGTGTGACCTCACCCGCCTCTGCCAGTGGGTGCGAGAGGGCGTGAGGGATTG TGGGAAGGCTGTTGGATATGATGCAGACAGCGATGAATGCAACTCCCACACACTGGCCCTCCTCAGCCCT CTCCACACAGACACACGCACGCATGTGCGGTGCTTCTGCTCCTTCATTTCCTGATGCGGTTTCTTTACTA TTTATGTTTTCCCCTGTTTTGGTTTCGCGGAATATGGACGCACGAACGCAGAGAGCAGAGGCGCGACACA CACACACGGGGCGCACACGTGTAAGCGACGGAGCGCGACACAGAGGGGAGAAGCCGGAAAGGATATATGA AATGAAGATGGTGTCCCGCACACACAGGCACGCACACGGGGCGAACGCGTGGCGCGTCCTTTCTATGGTT TCGCTGCTGCTGTTCGTGTTCTCGCTTCGCTGGTTGCAGTTCCGGCTCGTGCTGCCCTGCCTGCCACTCT TGGTCCGTGTCTGTCCGTGTCCGTGTCCGTGTGGGGGGGGGAGAGTTTTTCACTCCCCCGGTCACCTCTA CTGTTTATTATTTATATGTTTATTTATTTCCATATTGACTCAATTCATTCCGTGCGAAAGCCGGCTTGTT CCGGCGTCTTTTGACGAACAACTGCCCTATCAGCTGGTGATGGCCGTGTAGTGGACTGCCATGGCGTTGA CGGGAGCGGGGGATTAGGGTTCGATTCCGGAGAGGGAGCCTGAGAAATAGCTACCACTTCTACGGAGGGC AGCAGGCGCGCAAATTGCCCAATGTCAAAACAAAACGATGAGGCAGCGAAAAGAAATAGAGTTGTCAGTC CATTTGGATTGTCATTTCAATGGGGGATATTTAAACCCATCCAATATCGAGTAACAATTGGAGGACAAGT CTGGTGCCAGCACCCGCGGTAATTCCAGCTCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAA
Protein Sequence	>AAC31146.1 thiol specific antioxidant [Leishmania major] MSCGNAKINSPAPSFEEVALMPNGSFKKISLSSYKGKWVVLFFYPLDFSFVCPTEVIAFSDSVSRFNELN CEVLACSIDSEYAHLQWTLQDRKKGGLGTMAIPMLADKTKSIARSYGVLEESQGVAYRGLFIIDPHGMLR QITVNDMPVGRSVEEVLRLLEAFQFVEKHGEVCPANWKKGAPTMKPEPNASVEGYFSKQ
Molecule Role	Protective antigen
Molecule Role Annotation	Researchers evaluated the potency of different DNA vaccine candidates in BALB/c mice using high dose footpad parasite challenge with L. major. Mice inoculated pCMV3ISS-TSA developed significantly smaller lesions in their footpads after challenge with the parasite. The vaccine was able to induce a partially protective effect (Ahmed et al., 2009).
Related Vaccines(s)	L. major DNA Vaccine encoding LACKp24, TSA, LmSTI1 and CPa , L. major DNA vaccine encoding TSA, LMSTI1, KMP11, and LACK , LEISH-F1+MPL-SE
References

TSA