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hslU

Gene Name hslU
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium
VO ID VO_0011266
NCBI Protein GI 9650897
Other Database IDs CDD:235364
GOA:O30911
InterPro: IPR003593
InterPro: IPR004491
InterPro: IPR013093
UniProtKB/UniProt: O30911
Taxonomy ID 90371
Protein Name heat shock protein
Protein pI 5.22
Protein Weight 47057.28
Protein Length 540
Protein Note ATP-dependent protease ATP-binding subunit HslU; Provisional; PRK05201
Protein Sequence
>CAC00720.1 heat shock protein [Salmonella enterica subsp. enterica serovar Typhimurium]
MSEMTPREIVSELNKHIIGQDNAKRSVAIALRNRWRRMQLDEELRHEVTPKNILMIGPTGVGKTEIARRL
AKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAK
NNWGQAEQQQEPSAARQTFRKKLREGQLDDKEIEINLAAAPMGVEIMAPPGMEEMTSQLQSMFQNLGGQK
QKPRKLKIKDAMKLLVEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRGETSGPDVSREGVQRD
LLPLVEGCTVSTKHGMVKTDHILFIASGAFQVAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNAS
VTVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNETTENIGARRLHTVLERLMEEISYNASDLHGQNITI
DAEYVSKHLDALVADEDLSRFIL

Molecule Role Protective antigen
Molecule Role Annotation Study demonstrated that a recombinant construction of heat-shock protein (hslU) with lypopolysaccharide (rcHSP-LPS) administered 24 hours before inoculation induced resistance to S. typhimurium infection. Protection formed after 3 injections of rcHSP-LPS with 10 mcg in each or single injection with 100 mcg/mouse. Forty to eighty percent of immunized mice survived after challenge while 90% of control animals died. Destruction of the HSP by boiling of the construction led to loss of protective effect (Vorob'ev et al., 2009).
References