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phl p I
Gene Name	phl p I
Sequence Strain (Species/Organism)	Phleum pratense
NCBI Protein GI	473360
3D structure: PDB ID	1N10
Other Database IDs	CDD:165628 CDD:281341 CDD:279671 GOA:P43213 InterPro: IPR005795 InterPro: IPR007112 InterPro: IPR007117 InterPro: IPR007118 InterPro: IPR009009 InterPro: IPR014733 PDB: 1N10 UniProtKB/UniProt: P43213
Taxonomy ID	15957
Protein Name	Phl p I allergen
Protein pI	6.51
Protein Weight	27025.35
Protein Length	315
Protein Note	expansin A; Provisional
Protein Sequence	>CAA55390.1 Phl p I allergen [Phleum pratense] MASSSSVLLVVVLFAVFLGSAYGIPKVPPGPNITATYGDKWLDAKSTWYGKPTGAGPKDNGGACGYKDVD KPPFSGMTGCGNTPIFKSGRGCGSCFEIKCTKPEACSGEPVVVHITDDNEEPIAPYHFDLSGHAFGAMAK KGDEQKLRSAGELELQFRRVKCKYPEGTKVTFHVEKGSNPNYLALLVKYVNGDGDVVAVDIKEKGKDKWI ELKESWGAIWRIDTPDKLTGPFTVRYTTEGGTKTEAEDVIPEGWKADTSYESK
Molecule Role	Protective antigen
Molecule Role Annotation	On the basis of the experimentally determined B cell epitopes of Phl p 1, five synthetic peptides have been synthesized. These peptides are derived from the major Phl p 1 IgE epitopes and were between 28-32 amino acids long. When used as immunogens in mice and rabbits, the peptides induced protective IgG antibodies, which recognized the complete Phl p 1 wild-type allergen and group 1 allergens from other grass species. Moreover, peptide-induced antibodies inhibited the binding of grass pollen allergic patients IgE antibodies to the wild-type allergen (Focke et al., 2001).
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