VIOLIN: Vaccine Investigation and Online Information Network

NS1 (non-structural protein 1)
Gene Name	NS1 (non-structural protein 1)
VO ID	VO_0011259
Other Database IDs	CDD:109983
Taxonomy ID	11089
Protein Name	non-structural protein NS1
Protein Length	352
Protein Note	virion RNA mosquito-borne
Protein Sequence	>gi\|27735290\|ref\|NP_776002.1\| non-structural protein NS1 [Yellow fever virus] DQGCAINFGKRELKCGDGIFIFRDSDDWLNKYSYYPEDPVKLASIVKASFEEGKCGLNSVDSLEHEMWRS RADEINAIFEENEVDISVVVQDPKNVYQRGTHPFSRIRDGLQYGWKTWGKNLVFSPGRKNGSFIIDGKSR KECPFSNRVWNSFQIEEFGTGVFTTRVYMDAVFEYTIDCDGSILGAAVNGKKSAHGSPTFWMGSHEVNGT WMIHTLEALDYKECEWPLTHTIGTSVEESEMFMPRSIGGPVSSHNHIPGYKVQTNGPWMQVPLEVKREAC PGTSVIIDGNCDGRGKSTRSTTDSGKVIPEWCCRSCTMPPVSFHGSDGCWYPMEIRPRKTHESHLVRSWV TA
Molecule Role	Protective antigen
Molecule Role Annotation	Protection from lethal viral infection has been achieved with passively administered monoclonal antibody specific for flavivirus glycoprotein NS1 (Pincus et al., 1992). Immunization of monkeys with yellow fever virus-specified nonstructural protein NS1 resulted in protection against fatal hepatitis as well as marked reduction in the magnitude of viremia after subcutaneous challenge with yellow fever virus (Schlesinger et al., 1986).
Related Vaccines(s)	Yellow Fever NS1 Protein Vaccine
References