VIOLIN: Vaccine Investigation and Online Information Network

VP4
Gene Name	VP4
Sequence Strain (Species/Organism)	Murine rotavirus
VO ID	VO_0011255
NCBI Protein GI	475695
Other Database IDs	CDD:189541
Taxonomy ID	28327
Gene Strand (Orientation)	?
Protein Name	VP4
Protein pI	5.09
Protein Weight	81238.63
Protein Length	822
Protein Note	Outer Capsid protein VP4 (Hemagglutinin); pfam00426
Protein Sequence	>AAA50492.1 VP4 [Murine rotavirus] MASLIYRQLLTNSFTVDISDEIETIGAEKTQNVTVNPGPFAQTGYAPANWGPGETNDSTTVEPMLDGPYQ PIAFSPPPEYYILLSPTAPGVIAECTNTVNRWIAIIAIEPNVSTTNRTYTLFGITEQLTVENSSVDKWKF IDFMKTPTTGSYVRYNILLSSTKLCAVAKHTDNLYSYVGETPTAGQAYYSSFNIFNLTAHCDFYIIPWSQ QSLCTQYVNNGLPPIQNTRNVVPRHLSARSIITQRAQANEDIVVSKTSLWKEMQFNRDITIRFKFANAII KSGGLGYKWSEISFKPANYQYTYTRDGEEVTAHTTCSVNGVNNFDFFGGSLPTDFGISRYEVIKENSFVY IDYWDDSQAFRNMVYVRSLAADLNTVECTGGAYSFSLPVGQWPVMTGGAVSLRAAGVTLSTQFTDFVSLN SLRFRFRLSVEEPSFSITRTRVSGLYGLPAADPNNGREYYEIAGRFSLISLVPSNDNYQTPIMNSVTVRQ DLERQLGELREEFNALSQEIALSQLVDLALLPLDMFSMFSGIKATLDVAKSMATNVMKKFKKSGLATSIS AMTESLSDAASSVSRSGAIRSVSSTSSAWTDVSSRVANVENAASTVSTQTATISRRLRLKEITTQTEGMN FDDISAAVLKTKLDKSVQIAPNTLPDIVTEASEKFIPNRSYRVINNNEAFETGTDGRFFAYRVDTLEELP FDVQKFADLVAESPVISAIIDFKTLKNLNDNYGISKEQAFSLLRSDPRVLREFINQGNPIIRNRIEQLIM QCRL
Molecule Role	Protective antigen
Molecule Role Annotation	Plasmid DNA vaccines encoding for murine rotaviral proteins VP4, VP6, and VP7 were tested in adult BALB/c mice for their ability to induce immune responses and provide protection against rotavirus challenge. Vaccines encoding VP4 were effective in protecting mice against infection after rotavirus (100 ID50) challenge (Herrmann et al., 1996).
References

VP4