VIOLIN: Vaccine Investigation and Online Information Network

SAG1
Gene Name	SAG1
Sequence Strain (Species/Organism)	Sarcocystis neurona 3106
VO ID	VO_0011253
NCBI Protein GI	295682690
Other Database IDs	CDD:252367
Taxonomy ID	42890
Gene Strand (Orientation)	?
Protein Name	surface antigen 1
Protein pI	7.22
Protein Weight	26504.924
Protein Length	333
Protein Note	SRS domain; pfam04092
Protein Sequence	>ADG26774.1 surface antigen 1 [Sarcocystis neurona] MTRAVLLTFLTLCSARVSLVRAGAPPQATCANGETTVTKLGSSGALRIHCPNNFRLAPRAGNDAGQMQVY ATAVAENPVNIRDVLPGASYLSVQNVPTLTVPQLPAKATSVFFHCQQQPDNQCFIQVEVAPAPRLGPNTC AALQSTIAFEVQQANETAVFSCGEGLAVFPQGSKALDEACSKEQALPSGAALAPKDGGLHLGFPQLPQQA MKICYICTNGGVQAEAAQRCEVRISVAANPDGSVPGANGAASXGAAARSAXALGLALVAGAFLHFC
Molecule Role	Protective antigen
Molecule Role Annotation	Horses were vaccinated with adjuvanted recombinant SnSAG1 (rSnSAG1)and 5 control (sham vaccinated) horses were vaccinated with adjuvant only. The effect of vaccination with rSnSAG1 on in vivo infection by S. neurona was evaluated by challenging all the horses with S. neurona merozoites. The study showed that vaccination with rSnSAG-1 produced antibodies in horses that neutralized merozoites when tested by in vitro culture and significantly reduced clinical signs demonstrated by in vivo challenge (Ellison and Witonsky, 2009).
Related Vaccines(s)	S. neurona SAG1 Protein Vaccine
References