VIOLIN: Vaccine Investigation and Online Information Network

US6
Gene Name	US6
Sequence Strain (Species/Organism)	Suid alphaherpesvirus 1
VO ID	VO_0011240
NCBI Gene ID	2952521
NCBI Protein GI	51557553
Locus Tag	SuHV1_gp68
Genbank Accession	BK001744
Protein Accession	YP_068387
Taxonomy ID	10345
Gene Starting Position	121023
Gene Ending Position	123397
Gene Strand (Orientation)	+
Protein Name	envelope glycoprotein D
Protein pI	9.38
Protein Weight	41362.03
Protein Length	400
Protein Note	envelope glycoprotein D; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; the nonessential glycoprotein gC interacts with cell surface proteoglycans, whereas the essential glycoprotein gD is involved in stable secondary attachment
DNA Sequence	>NC_006151.1:121023-123397 Suid herpesvirus 1, complete genome CCATAAAATTGGGTGGGGGCCCCAGGTTCCCATACACTCACCTGCCAGCGCCATGCTGCTCGCAGCGCTA TTGGCGGCGCTGGTCGCCCGGACGACGCTCGGCGCGGACGTGGACGCCGTGCCCGCGCCGACCTTCCCCC CGCCCGCGTACCCGTACACCGAGTCGTGGCAGCTGACGCTGACGACGGTCCCCTCGCCCTTCGTCGGCCC CGCGGACGTCTACCACACGCGCCCGCTGGAGGACCCGTGCGGGGTGGTGGCGCTGATCTCCGACCCGCAG GTGGACCGGCTGCTGAACGAGGCGGTGGCCCACCGGCGGCCCACGTACCGCGCCCACGTGGCCTGGTACC GCATCGCGGACGGGTGCGCGCACCTGCTGTACTTTATCGAGTACGCCGACTGCGACCCCAGGCAGATCTT TGGGCGCTGCCGGCGCCGCACCACGCCGATGTGGTGGACCCCGTCCGCGGACTACATGTTCCCCACGGAG GACGAGCTGGGGCTGCTCATGGTGGCTCCGGGGCGGTTCAACGAGGGCCAGTACCGGCGCCTGGTGTCCG TCGACGGCGTGAACATCCTCACCGACTTCATGGTGGCGCTCCCCGAGGGGCAAGAGTGCCCGTTCGCCCG CGTGGACCAGCACCGCACGTACAAGTTCGGCGCGTGCTGGAACGACGAGAGCTTCAGGCGGGGCGTGGAC GTGATGCGATTCCTGACGCCGTTCTACCAGCAGCCCCCGCACCGGGAGGTGGTGAACTACTGGTACCGCA AGAACGGCCGGACGCTCCCGCGGGCCTACGCCGCCGCCACGCCGTACGCCATCGACCCCGCGCGGCCCTC GGCGGGCTCGCCGAGGCCCAGGCCCCGGCCCCGGCCCCGGCCGAAGCCCGAGCCCGCCCCGGTGACGCCC GCGCCCCCCGGCCGCCTGCCCGAGCCGGCGACGCGGGACCACGCCGCCGGGGGCCACCCCACGCCGCGAC CCCCGAGGCCCGAGACGCCGCACCGCCCCTTCGCCCCGCCGGCCGTCGTGCCCAGCGGGTGGCCGCAGCC CGCGGAGCCGTTCCAGCCGCGGACCCCCGCCGCGCCGGGCGTCTCGCGCCACCGCTCGGTGATCGTCGGC ACGGGCACCGCGATGGGCGCGCTCCTGGTGGGCGTGTGCGTCTACATCTTCTTCCGCCTGAGGGGGGCGA AGGGGTATCGCCTCCTGGGCGGTCCCGCGGACACCGACGAGCTAAAAGCGCAGCCCGGTCCGTAGCCTCC GCAGTACCGGCGTCGATGATGATGGTGGCGCGCGACGTGACCCGGCTCCCCGCGGGGCTCCTCCTCGCCG CCCTGACCCTGGCCGCCCTGACCCCGCGCGTCGGGGGCGTCCTCTTCAGGGGCGCCGGCGTCAGCGTGCA CGTCGCCGGCAGCGCCGTCCTCGTGCCCGGCGACGCGCCCAACCTGACGATCGACGGGACGCTGCTGTTT CTGGAGGGGCCCTCGCCGAGCAACTACAGCGGGCGCGTGGAGCTGCTGCGCCTCGACCCCAAGCGCGCCT GCTACACGCGCGAGTACGCCGCCGAGTACGACCTCTGCCCCCGCGTGCACCACGAGGCCTTCCGCGGCTG TCTGCGCAAGCGCGAGCCGCTCGCCCGGCGCGCGTCCGCCGCGGTGGAGGCGCGCCGGCTGCTGTTCGTC TCGCGCCCGGCCCCGCCGGACGCGGGGTCGTACGTGCTGCGGGTCCGCGTGAACGGGACCACGGACCTCT TTGTGCTGACGGCCCTGGTGCCGCCCAGGGGGCGCCCCCACCACCCCACGCCGTCGTCCGCGGACGAGTG CCGGCCCGTCGTCGGATCGTGGCACGACAGCCTGCGCGTCGTGGACCCCGCCGAGGACGCCGTGTTCACC ACGCCGCCCCCGATCGAGCCAGAGCCGCCGACGACCCCCGCGCCCCCCCGGGGGACCGGCGCCACCCCCG AGCCCCGCTCCGACGAAGAGGAGGAGGACGAGGAGGGGGCGACGACGGCGATGACCCCGGTGCCCGGGAC CCTGGACGCGAACGGCACGATGGTGCTGAACGCCAGCGTCGTGTCGCGCGTCCTGCTCGCCGCCGCCAAC GCCACGGCGGGCGCCCGGGGCCCCGGGAAGATAGCCATGGTGCTGGGGCCCACGATCGTCGTCCTCCTGA TCTTCTTGGGCGGGGTCGCCTGCGCGGCCCGGCGCTGCGCGCGGAATCGCATCTACCGGCCGCGACCCGG GCGCGGCCCGGCGGTCCACGCGCCGCCCCCGCGGCGCCCGCCCCCCAGCCCCGTCGCCGGGGCGCCCGTC CCCCAGCCCAAGATGACGTTGGCCGAGCTTCGCCAGAAGCTGGCCACCATCGCAGAGGAACAATA
Protein Sequence	>YP_068387.1 envelope glycoprotein D [Suid alphaherpesvirus 1] MLLAALLAALVARTTLGADVDAVPAPTFPPPAYPYTESWQLTLTTVPSPFVGPADVYHTRPLEDPCGVVA LISDPQVDRLLNEAVAHRRPTYRAHVAWYRIADGCAHLLYFIEYADCDPRQIFGRCRRRTTPMWWTPSAD YMFPTEDELGLLMVAPGRFNEGQYRRLVSVDGVNILTDFMVALPEGQECPFARVDQHRTYKFGACWNDES FRRGVDVMRFLTPFYQQPPHREVVNYWYRKNGRTLPRAYAAATPYAIDPARPSAGSPRPRPRPRPRPKPE PAPVTPAPPGRLPEPATRDHAAGGHPTPRPPRPETPHRPFAPPAVVPSGWPQPAEPFQPRTPAAPGVSRH RSVIVGTGTAMGALLVGVCVYIFFRLRGAKGYRLLGGPADTDELKAQPGP
Molecule Role	Protective antigen
Molecule Role Annotation	The pseudorabies virus (PrV) DNA vaccine carrying the glycoprotein D (gD) gene delivered by E. coli was able to induce protective immune responses in mice against a lethal PrV challenge (Shiau et al., 2001). Immunization of mice with affinity-purified gD of Aujeszky's disease virus (ADV, Suid herpesvirus 1) induced a strong humoral immune response and protected mice against lethal ADV challenge (Vrublevskaia et al., 2007).
References

US6