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Kbeta

Gene Name Kbeta
Sequence Strain (Species/Organism) Plasmodium falciparum 3D7
VO ID VO_0011233
NCBI Gene ID 813054
NCBI Protein GI 124506397
Locus Tag PF3D7_0524000
Genbank Accession AL844504
Protein Accession XP_001351796
Taxonomy ID 36329
Chromosome No 5
Gene Starting Position 998752
Gene Ending Position 1002123
Gene Strand (Orientation) +
Protein pI 4.54
Protein Weight 120404.67
Protein Length 1123
DNA Sequence 
>NC_004326.2:998752-1002123 Plasmodium falciparum 3D7 chromosome 5
AATGGATAAAATTGTAGAAGTTATTGAAGGATTAAGCAGCTCTGAGAGTCATATAAGAAATGAATGTGAA
AATACGTTAAATTATTATAAAAAGAATGATTTAAATAATACAGTATTATCTATATTGAAATTATTAAAAA
CCCATAAAGATAGTCAAGTTCGATTACAATGTGCTATATTAATTAGGAATATATTTCGTGTGTATATAAA
GTCCACACATGTGGATGTGGAAGAAAAAGAAAAAAATGAGAATTCGATTGGAAATGCAGAAGAAGAGAAT
TATTGGGTATTATTACCTGATAATTTAAAGAATATTGTAAAATCTGAATTGATTAGTAATATAGGAACTG
AAACAGATAAGATGGTTCGAAGTAATATATGTAATAATATTATAGATTTATCATCAAAATTATTATTACA
TAATCAATGGCCTGAGTTATTATCAGTAACATTTGAATTTTGTAATTCTAATAACGTTGATGTATTAATA
AGTGGATATAAAATATTAGGTGGTATCTTAAGTTGTATTCCAGATGAATTAGATGGAAAACAAGAAATAA
TATCTTCCATATGTATGAAAGGTTTAAATTCATCAAATGTACAAGTACGTGGAGAATGTATTAATTTAAT
ATCATGTATTGTTGAAGATAATAGTTCATCCTTAGTTAAGAGTGTACATGGTTGTATCCCATTAATATTA
CAATCATTAAGTTTGATGGCAAAGAATAGTAGTTCAGATATTGCTGTTCTAGAAGAATGTGAGAAAGTAC
TTCAATCTATTGGTAAAATGATAGATTATAATGCTAAATTTTTTACTAAGCATATAACAAGTTTGTGTGA
TATATTATTTAGTATTTGTATGAAAGATGAAAATGAATTGAACTATGATTTTGATAATAGCTTGAAGTCC
CTAAGTATTGAAGCTTTAGTTACCATTCCAGAACGTCGACCAAAAATGGCTTTATCTGTACCTCATTTTG
TAGATAAGATTATACATTTGTCTATGTTATTTATGCTTGACATTAATAATGATTGTTTTAATGAATGGAT
GAATTCTATAAAAGAAGGTAAAGACGATAGTCAGGAGTTATATGACATAGGTGAAGAGTCCTTAGATCGT
GTTGGTAAAGCATTTAGTGAGTTAGAAGAAGCTGAATTTATTCATATTCTTTTTAATAAAGTATCAGAAT
TTTTAATGAAAAATACTTGGGAACATAAATATGTCGGTATTATGGCTATTGCACAAACTATAGAATATTT
ACCAGAAGATGAAATTGAAGAACAATTAGAACATGTTATAAAAATGTTGTTACAAATATTAGTTGATCAA
GATGTTAGAGTACGTTATGCAGCATGTCAAGCCATTGGACAAATATCTTTAGATCATCAACCATATGTAC
AGAAAGAATTTTTTTCAGAAATTTTATCAGCATTAATTAATACCATGAACGATGTACATTTAAGAGTTCA
ATCACATGCTACAGCAGCTTTTGTAAATTATGCAGAAGAATTAGATAAAATGGCTTTATTACCATATGCA
GATATTATTATAGATATTTTATTACAAAAATTGAATTCTTCAAATTATTTATTAGTAAGAGAACAAGCTG
TTACTGCTATAGCGGTTATTGCAGGTGTTATTGAAGAAGACTTTTTAAAATATTATTCTACTGTTGTACC
TATGATGAAAGATATTATTCAAAAGGCAGTTTCTGAAGAAGAAAGAACATGCAGAGGTAAAGCCATTGAA
TGTATTTCAATTATTGGTTTATCGGTTGGTAAAGATATTTTTATTGAAGATGCTAAAGAATGTATGAATG
CATTATTACAAATTAGCAGTACAAAAATGGATCCTGATGATACTGTAAAAGAATATATTCAAGAAGCTAT
TGGTCGTATATGTAGAGCATTAGGTAATGACTTTTATCCATATCTAAGTAGTATAGTACCGACCATATTA
TCTGTACTCTCCGTTTTACCAAAACCATTAACAGATGATGAAGAAGATCTAACCATAACTATGGTATCTA
ATGGACAATATGTAGGATTGAAAACATCCTTATTAGAAGATCAAGAAAAAGCTTTAGATTTATTAATTAT
TATTATTGAAGTATTAAAAGAAAATTATAAGGATTATATTCAAGCAACAGCTACAGCTGTGTTGCCAATG
TTAAATTATGAATTGTCAGATGAAATTAAACAAAAGGCATTAACAGCTGTTAGTGAATTAATTGAATCAG
CAAGAATATTATCTGAAAAAACGGATAATGATAAATCCATGTTACTAGCCATATTAACAGCAGCAGCAGA
AAAAGTATTAAAAAGTCTATTAGAAACAAAATTAGATGACAATTATGAATATATATTAGATGTTATGATA
ATCGAATCCCATGGATTATATATGTGCTTACAAAAAGCGGGATCGAATGTATTGCCAGAAAATACATTAA
AATTATTTTTTAATCAAATCTTTGCCCTATTACAATATTCAACAGATAGAAGGGTAGTATATAATCAAAA
AAAAAATAATGATGATGTAGATGAAGATGAATTATTAATAATTGATAGAGAAGAGGAATTAGAACAGAAT
TATCGAACAAATTTATTAGATATCTTAGGAGTATTAATTAAATATCACCCAACACAATTCTTAAATACAT
GTTGTGAATTATGTATTGGATTTATTAATAATTATATGAATTCTCCTAATTCAGAAGATGTAGCATTAGC
ATTATATGTATGTGATGATTTGTTAGAATTCTTACAAGAAAAGAGTGTAAACCTATGGGACTTTTTCATG
AACCCATTATTATTAAATATTAATCATGCAGATGATAAAGTAAAACAAGCGGCATGTTATGGTGTTATAC
AAGCAACCAAAATTGAAGCATTTGGAAAGTATGCAAATATTGCAGTAGAATATTTATTAAAATTAGTACA
TGAAAGTACATCAAATAAAAAACCAAAAGAATATATCTCAGCTATTGATAATGCTATAGCAGCATTAGGT
GATGTTGTTCTTATGCATACATCAAAATTTAATAATGCAGAAGATCTCATAAAAGTATGGTTAAATCATT
TACCAATAAAAGAAGATGATGCAGAAGGTAGAAGAGTACATAAAAATCTTATAGATTTAGTTTCACAAAA
CCATCCTCTCTTGTTCGGAAAAGATAATTCTAATACAGCAAAAATTATTGAAATATTCTTAACAATATAT
GAAACTGATTTTTCAGATACTGACTGTAACAAAAAAATCTCAACACTTATCAATTCATTGGATAAATCAT
ATTTAAATAATTTAGCTTCTTCAACTTTGTCACATAAGCAAGCCAAAAAATTGAACAACATTTTGAATCC
AAACAGAAAATA
Protein Sequence 
>XP_001351796.1 karyopherin beta [Plasmodium falciparum 3D7]
MDKIVEVIEGLSSSESHIRNECENTLNYYKKNDLNNTVLSILKLLKTHKDSQVRLQCAILIRNIFRVYIK
STHVDVEEKEKNENSIGNAEEENYWVLLPDNLKNIVKSELISNIGTETDKMVRSNICNNIIDLSSKLLLH
NQWPELLSVTFEFCNSNNVDVLISGYKILGGILSCIPDELDGKQEIISSICMKGLNSSNVQVRGECINLI
SCIVEDNSSSLVKSVHGCIPLILQSLSLMAKNSSSDIAVLEECEKVLQSIGKMIDYNAKFFTKHITSLCD
ILFSICMKDENELNYDFDNSLKSLSIEALVTIPERRPKMALSVPHFVDKIIHLSMLFMLDINNDCFNEWM
NSIKEGKDDSQELYDIGEESLDRVGKAFSELEEAEFIHILFNKVSEFLMKNTWEHKYVGIMAIAQTIEYL
PEDEIEEQLEHVIKMLLQILVDQDVRVRYAACQAIGQISLDHQPYVQKEFFSEILSALINTMNDVHLRVQ
SHATAAFVNYAEELDKMALLPYADIIIDILLQKLNSSNYLLVREQAVTAIAVIAGVIEEDFLKYYSTVVP
MMKDIIQKAVSEEERTCRGKAIECISIIGLSVGKDIFIEDAKECMNALLQISSTKMDPDDTVKEYIQEAI
GRICRALGNDFYPYLSSIVPTILSVLSVLPKPLTDDEEDLTITMVSNGQYVGLKTSLLEDQEKALDLLII
IIEVLKENYKDYIQATATAVLPMLNYELSDEIKQKALTAVSELIESARILSEKTDNDKSMLLAILTAAAE
KVLKSLLETKLDDNYEYILDVMIIESHGLYMCLQKAGSNVLPENTLKLFFNQIFALLQYSTDRRVVYNQK
KNNDDVDEDELLIIDREEELEQNYRTNLLDILGVLIKYHPTQFLNTCCELCIGFINNYMNSPNSEDVALA
LYVCDDLLEFLQEKSVNLWDFFMNPLLLNINHADDKVKQAACYGVIQATKIEAFGKYANIAVEYLLKLVH
ESTSNKKPKEYISAIDNAIAALGDVVLMHTSKFNNAEDLIKVWLNHLPIKEDDAEGRRVHKNLIDLVSQN
HPLLFGKDNSNTAKIIEIFLTIYETDFSDTDCNKKISTLINSLDKSYLNNLASSTLSHKQAKKLNNILNP
NRK
Molecule Role Protective antigen
Molecule Role Annotation Two large fragments of PfKbeta representing the N- and C-terminal halves were expressed in E. coli. The recombinant proteins were highly immunogenic in mice, and also found to be the target for immune response in natural infections of Plasmodium spp. Immunization with recombinant PfKbeta fragments was partially protective against a heterologous challenge infection in mice (Mohmmed et al., 2005).
References