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MSP1 from P.vivax

Gene Name MSP1 from P.vivax
Sequence Strain (Species/Organism) Plasmodium vivax
VO ID VO_0011230
NCBI Nucleotide GI AF435639.1
NCBI Protein GI 26985160
3D structure: PDB ID 2NPR
Other Database IDs CDD:299863
CDD:284802
CDD:289698
CDD:289699
Taxonomy ID 5855
Gene Strand (Orientation) ?
Protein Name merozoite surface protein 1
Protein pI 7.06
Protein Weight 187587.32
Protein Length 1844
Protein Note The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013
Protein Sequence 
>AAN86248.1 merozoite surface protein 1 [Plasmodium vivax]
MKALLFLFSFIFFVTKCQCETESYKQLVAKLDKLEALVVDGYELFHKKKLGESDIQVETNASANNNNNNQ
VSVLTSKIRNFVGKFLELQIPGHTDLLHLIRELAFEPNGIKYLVESYEEFNQLMHVINFHYDLLRAKLHD
MCAHDYCKIPEHLKISDKELDMLKKVVLGYRKPLDNIKDDIGKLETFITKNKITIKNISDLIIAENKKRS
GHPTTTTNGAGTQPANGSIAAASSETTQISGSSNSGSTGHGSSNSGSTGHGSSNSGSSGTGSSNSGSSGT
GSTGNGQSPPATADASSTNANYEAKKIIYQAVYNTIFYTNQLQEAQKLIAVLEKRVKVLKEHKDIKVLLE
KIATEKGKFPNNNLNVENPTDEQKTAKSNIADLEKKIEAIAKTVNFDLDGLFTDAEELEYYLREKAKMAG
TLIIPESTKSAGTPGKTVPTLKETYPHGISYALAENSIYELIEKIGSDETFGDLQNPDDGKQPKKGILIN
ETKRKELLEKIMNKIKIEEDKLPDLKKEYEEKYTVYEQKVKEFQPEFNYFYEARLDNTLVGEKFGEFKKK
REEYMKEKKKLESCSYEQNTNLINKLKKQLTYLEDYVLRKDIADDEIKHFSFMEWKLKSEIYDLAQEIRK
NENKLTIENKFDFSGVVELQVQKVLIIKKIEALKNVQNLLKNAKVKDDLYVPKVYKTGEKPEPYYLMVLK
REIDKLKDFIPKIESMIATEKNKPTVAAADIVAKGQSLRGASETGTTGNTVNAQTAVVQQPQHQVVNAVT
VQPGTTGHQAQGGEAETQTNSVQAAQVQQTPAGAGGQVASTQTTSQAPAPTQASPEPAPAAPPSTPAAAV
APAPAMSKLEYLEKLLDFLKSAYACHKHIFVTNSTMDKKLLKEYELNADEKTKINQNKCDELDLLFNVQN
NLPAMYSIYDSMSNELQNLYIELYQKEMVYNIYKNKDTDKKIKAFLETSNNKAAAPAQSAAKPSGQAGTT
PVTTTAPVTTTTVTPSPQTSVVTSTPPTPQAEENQRVGGNSEEKPEADTAQVEKFYEKHLSQIDKYNDYF
KKFLESKKEEIIKMDDTKWNALGKEIEELKKKLQVSLDHYGKYKLKLERFLKKKNKISNSKDQIKKLTSL
KNKLERRQNLLNNPTSVLKNYTAFFNKKRETEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEE
SMQKEDNYLNLEKFRVLSRLEGRLGKNIELEKENISYLSSGLLHVLTELKEIINDKKYSGKDHAKNIAEV
KKALQAYQELIPKVTSQESTSVAVTVPGAVVPGVPTAAAAGSGASGAVPPATGGVVPGVVESAEAQTQTQ
AQDYAEDYDKVIALPLFGNNDDDGEEDQVTTGEAESEAPEILVPAGISDYDVVYLKPLAGMYKTIKKQLE
NHVNAFNTNITDMLDSRLKKRNYFLEVLNSDLNPFKYSSSGEYIIKDPYKLLDLEKKKKLIGSYKYIGAS
IDKDLATANDGVAYYNKMGELYKTHLDGVKTEIKKVEDDIKTHDEKLQKLGSEVSQNSEKTQLNAKKAEL
EKYLPFLNSLQKEYESLVSKVNTYTDNLKKVINNCQLEKKEAEITVKKLQDYNKMDEKLEEYKKSEKKNE
VKSSGLLEKLMKSKLIKENESKEILSQLLNVQTQLLTMSSEHTCIDTNVPDNAACYRYLDGTEEWRCLLT
FKEEGGKCVPASNVTCKDNNGGCAPEAECKMTDSNKIVCKCTKEGSEPLFEGVFCSSSSFLSLSFLLLML
LFLLCMEL
Molecule Role Protective antigen
Molecule Role Annotation Immunization of BALB/c mice and Aotus monkeys with PvMSP-1 induced IgG antibodies (titer > 10(6)) that cross-reacted with P. vivax parasites. Immunized monkeys displayed partial protection against a challenge with P. vivax blood stages (Valderrama-Aguirre et al., 2005).
References