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FCR3S1.2-var1

Gene Name FCR3S1.2-var1
Sequence Strain (Species/Organism) Plasmodium falciparum
VO ID VO_0011229
NCBI Gene ID 810160
NCBI Protein GI 2961468
Other Database IDs CDD:292087
CDD:283158
CDD:281064
CDD:114603
CDD:292085
Taxonomy ID 5833
Gene Strand (Orientation) ?
Protein Name erythrocyte membrane protein 1
Protein pI 5.45
Protein Weight 244016.11
Protein Length 2328
Protein Note N-terminal segments of PfEMP1; pfam15447
Protein Sequence 
>AAC05730.1 erythrocyte membrane protein 1 [Plasmodium falciparum]
MATSGGSGGTQDEDAKHVLDEFGQKVHDEVHGEAKNYVSELKGSLSLASILGETAFTVKSMQTESKYTEL
IEANSKRNPCKKDGKGNDVDRFSVKEQAGYDNKKMKCSNGMTCAPFRRLHLCNKNFPNMNSNDSSKAKHD
LLAEVCMAAKYEGESIKTHYPKYDSKYPGSDFPMCTMLARSFADIGDIIRGRDLYLGNKKKKQNGKETER
EKLEQKLKEIFKKIHDNLKDKEAQKRYNGDEDPNFYKLREDWWTANRETVWGAMTCSKELDNSSYFRATC
NDTGQGPSQTHNKCRCDKDKGANAGKPKAGDGDVTIVPTYFDYVPQYLRWFEEWAEDFCRKKKKKLENLE
KQCRGKDKSDEYRYCSRNGYDCEQTISRKGKVRMGKGCTDCFFACHSYENWIDNQRKQFDKQKKYTKEIS
DGGGRKKRAVGGTTKYEGYEKSFYEKLKNDGYGTVDAFLGLLNNEKACKDITDGGKINFKEVNSGGGVVG
GGSGGTSGASGTNDENKGTFYRSEYCQPCPDCGVQHKGGNQWERKTKVKKMRWSKLYKPINGKMVLLLKS
LKVVKDMMILKKNWKEFCLTQNSSDGSVGSVVTTGASGGNSEKKELYDEWKCYKHNEVQKVNVQGEVEED
DDELKGAGGLCILPNPKKNKEVSEAKSQNNHADIQKTFHDFFYYWVAHMLKDSIHWRTKRLKSCISDGKT
MKCRNGCNKKCDCFEKWVKQKETEWKPIKDHFKTQEGIPEGYYFTTLELILKLQFLKEDTEENTENSLDA
EEAEELKHLQKILKLENENNLAVVNAGTEQKTLMDKLLNHELNDATKCKDCPLPEEDKSRGRSADPSPDI
FIPRPEEKEDDENEDDDEDEVRDDEETAKETTEGSATDTTTSLDVCPIVGKVLTKDNESLQDACSLKYGG
NNSRLGWRCVTPSGEPTTSSDKNGAICVPPRRRRLYIKKIVDWATKTESPQASGSEASSTSGSTTPPDSK
EALLKAFVESAAIETFFLWHRYKEEKKAVAQEGAGHGLPRVEEGSPEYDPEDKLKEGKIPDGFLRQMFYT
LGDYRDILFSGSNDTTSVSKDTPSSSNDNLKNIVLLASGSTEQEREKMNKYKEIKNFRKCSTERSAPNLV
SHPQTWWENNGKYIWHGMVCALTSKDKIAKGVEKKPQKIENPENLWDEANKKPKPPQYQYTNVKLDENSG
TSPRTTQTQASSDNTPTTLTHFVKRPTYFRWFEEWGESFCRERKKRLKQIKVDCKVENGDVGRCSGDGEA
CDSISTHDYSTVPSFNCPGCGKHCSSYRKWIERKKIEFHKQSNAYGQQKTDATRNNGNTFDKEFCKTLET
WPDAAKFLERLKNGPCKTNKEYGGDDIDFEKDSKTFQHTEYCGPCPKFKTNCQNGNCGVSGLNGNCDGKD
SIDAKEIAKMRSSTTDVVMRVSDNDTNTFEGDDLKDACQHANIFKGIRKDVWKCGYVCGVDICEQTNINE
RTDGKEYIQIRALFKRWVENFLEDYNKINDKISHCIKKGEGSKCINGCEKNSKCLEKWIEKKIAEWENIK
KRFNDQYENKDQPDYNVKSILEELIPKIAVVNDQDNVIKLCVFENSKGCTLISNTQNNKENDAIDCMLKK
LGVKAKNCPGKPSGEKQSDCKEPPPLPDEEDQNPEENTLEPPKFCPPTTQPPEEKGGETCGNKEEKKDEK
KEESEEPAKEESGPAAEEPAPTAESEETETNFPEPPGTGPAAPPSTPAPPTPDTPPPLRPQADEPFDSTI
LQTTIPFGVALALGSIAFLFLKKKTKASVGNLFQILQIPKSDYDIPTLKSSNRYIPYVSDRYKGKTYIYM
EGDSDEDKYAFMSDTTDVTSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSGNNTTASGKNTPSDTRND
IQNDGIPSSKITDNEWNQLKKEFISNMLQNQPNDVPNDYTSGNSSTNTNITTTSRHNVDNNTNTTMSRDN
MEENLLLPSIHDRNLYSGEEYSYNVNMVNSMNDIPINRDNNVYSGIDLINDSLSGGKPIDIYDEVLKRKE
NELFGTENTKRTSTQNVAKITNSDPIHNQLELFHKWLDRHRDMCEKWKNKEDILNKLKEEWNKENINNSG
KTYNSDNKPSHNHVLNTDVSIQIDMDNPKTKNEITNMDTNQDKSTMDTILDDLEKYNDPYYYDFYEDDII
YHDVDVEKSSMDDIYVDHNNVTSNNMDVPTKMHIEMNIVNNKKEIFEEEYPISDIWNI
Molecule Role Protective antigen
Molecule Role Annotation Immunized animals were challenged in vivo with various parasite strains or clones of malaria. Immunization with the PfEMP1-DBL1 alpha domain abolished the PfEMP1-dependent sequestration of the homologous strain in immunized rats and substantially inhibited parasite adhesion in immunized monkeys. Protection against sequestration of heterologous parasite strains was also confirmed by direct or indirect challenge in the rat model (Moll et al., 2007).
References