VIOLIN: Vaccine Investigation and Online Information Network

VP4
Gene Name	VP4
Sequence Strain (Species/Organism)	Bovine rotavirus
VO ID	VO_0011227
NCBI Protein GI	172054621
Other Database IDs	CDD:189541
Taxonomy ID	10927
Gene Strand (Orientation)	?
Protein Name	VP4
Protein pI	5.74
Protein Weight	31092.2
Protein Length	341
Protein Note	Outer Capsid protein VP4 (Hemagglutinin); pfam00426
Protein Sequence	>ACB71152.1 VP4, partial [Bovine rotavirus] ASLIYRQLLTNSYTVNLSDEIQEIGSAKSQDVTINPGPFAQTGYAPVNWGAGETNDSTTVEPLLDGPYQP TTFNPPTSYWVLLAPTVEGVIIQGTNNTDRWLATILIEPNVQTTNRIYNLFGQQVTLSVENTSQTQWKFI DVSTTTPTGSYTQHGPLFSTPKLYAVMKFSGRIYTYSGNTPNATTGYYSTTNYDTLNMTSFCDFYIIPRN QEEKCTEYINHGLPPIQNTRNVVPVSLSAREIVHTRAQVNEDIVVSKTSLWKEMQYNRDITIRFKFDRTI IKAGGLGYKWS
Molecule Role	Protective antigen
Molecule Role Annotation	Rotavirus structural proteins VP4, VP6 and VP7 from Bovine Rotavirus Strain C486 were cloned and expressed in a baculovirus expression system. Challenge of neonates born to animals immunized with VP4 protein on assembled particles or in cell lysates showed protection against challenge with both homologous (bovine C486) and heterologous (SA-11) strains of rotavirus (Redmond et al., 1993).
Related Vaccines(s)	Rotavirus VP4/VP7 Protein Vaccine
References