VIOLIN: Vaccine Investigation and Online Information Network

VP7
Gene Name	VP7
Sequence Strain (Species/Organism)	Bovine rotavirus
VO ID	VO_0011226
NCBI Protein GI	195661008
Other Database IDs	CDD:278842
Taxonomy ID	10927
Gene Strand (Orientation)	+
Protein Name	VP7
Protein pI	4.62
Protein Weight	35315.62
Protein Length	367
Protein Note	Glycoprotein VP7; pfam00434
Protein Sequence	>ACG50682.1 VP7 [Bovine rotavirus] MYGIEYTTILIFLTSITLLNYILKSITRMMDYIIYRFLLIAVILATMINAQNYGVNLPITGSMDTAYANS TQSEPFLTSTLCLYYPVEASNEMADTEWKDTISQLFLTKGWPTGSVYFKEYTDIAAFSVEPQLYCDYNLV LMKYDSTQKLDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISMGSSCTVKVCPLNTQTLGIGCLIT NPDTFETVATTEKLVITDVVDGVNHKLNVTTATCTIRNCKKLGPRENVAVIQVGGANILDITADPTTTPQ TERMMRINWKKWWQVFYTVVDYVNQIIQTMSKRSRSLNSSAFYYRV
Molecule Role	Protective antigen
Molecule Role Annotation	Rotavirus structural proteins VP4, VP6 and VP7 from Bovine Rotavirus Strain C486 were cloned and expressed in a baculovirus expression system. Neonates of animals immunized with virus-like particles composed of VP7 assembled on VP6 spherical particles were protected against challenge with the homotypic virus and significantly protected from a heterotypic challenge. Unassembled VP7 protein provided partial protection against challenge (Redmond et al., 1993).
Related Vaccines(s)	Rotavirus VP4/VP7 Protein Vaccine
References