VIOLIN: Vaccine Investigation and Online Information Network

CS from P. berghei str. ANKA
Gene Name	CS from P. berghei str. ANKA
Sequence Strain (Species/Organism)	Plasmodium berghei ANKA
VO ID	VO_0011217
NCBI Gene ID	3428738
NCBI Protein GI	AAA29577.1
Locus Tag	PBANKA_040320
Genbank Accession	LK023119
Protein Accession	XP_022712148
Taxonomy ID	5823
Chromosome No	4
Gene Starting Position	126554
Gene Ending Position	127576
Gene Strand (Orientation)	-
Protein pI	5.2
Protein Weight	35858.22
Protein Length	340
DNA Sequence	>NC_036162.1:126554-127576 Plasmodium berghei ANKA genome assembly PBANKA01, chromosome : 4 TTTAATTAAAGAATACTAATACTAATAATATTACAAATCCTAATGAATTGCTTACAATATTAAATATACT TGAACATTTATCCATTTTACAAATTTCAGTATCAATATCTTCTAAGGTCAAATCTTCTGCTTTCTTATTT GAACCTTTTCGTTTTCTAACTCTTATACCAGAACCACATGTTACGTTACATTGAGACCATTCCTCTGTGA TACTATCCCTGATCTGTTTAACAAATTCTAGTATTTTTTCCGCGCTTGGGATATAAGAATCGTCATTATT ATTATTTTTGTTATTGTTATTACCACCTGGCTGTGGTTGTGGCTGTGGTCGTGGCTGTGGTTGTGGCTGT GGCTGTGGTTGTGGCTGTGGCTGTGGTTGTGGCTGCGGCCGTGGCTGTGGTTGTGGATTGTTATTTCCTT GTGGTGGTGCTGGGTCATTTGGGTTTGGTGGTGGTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTTGG GTTTGGTGGTGGTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTT GCGTTTGGTGGTGCTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTTGCGTTTGGTGGTGGTGGGTCAT TTGCGTTTGGTGGTGGTGGGTCATTTGGGTTTGGTGGTGGTGGGTCATTTGGGTTTGGTGGTGGTGGGTC ATTTGGGTTTGGTGGTGGTGGGTCATTTGGGTTTGGTGGTGGTGGTGGTTGTTTCAATTTATTATTACGC TCTATTTTTTCGTTTTTTTTCTCATTTTTTTTTCCTTCGGGAGCATCGGCAAGTAATCTGTTGACTGTAT TTCGATTGTATATTTTTCCATTCTTAGAGTTAAGCACGTGATACAATTTATTATCATTTCCTTCATTGTA ACATAGCTCGTTTAAGTTCCTTTGGGCTTGGATGCTTTTATTTTGTCCATATCCTGGAAGTAGAGAATTA ACTAATAAAAGTGACGCTACAACTAAAATGGTACACTTCTTCA
Protein Sequence	>AAA29577.1 circumsporozoite protein [Plasmodium berghei ANKA] MKKCTILVVASLLLVNSLLPGYGQNKIIQAQRNLNELCYNEGNDNKLYHVLNSKNGKIYNRNTVNRLLPM LRRKKNEKKNEKIERNNKLKQPPPPPNPNDPPPPNPNDPPPPNPNDPPPPNPNDPPPPNANDPPPPNAND PAPPNANDPAPPNANDPAPPNANDPAPPNANDPAPPNANDPAPPNANDPPPPNPNDPAPPQGNNNPQPQP RPQPQPQPQPQPQPQPQPQPRPQPQPQPGGNNNNKNNNNDDSYIPSAEKILEFVKQIRDSITEEWSQCNV TCGSGIRVRKRKGSNKKAEDLTLEDIDTEICKMDKCSSIFNIVSNSLGFVILLVLVFFN
Molecule Role	Protective antigen
Molecule Role Annotation	Researchers produced a prototypic malaria vaccine based on a highly versatile self-assembling polypeptide nanoparticle (SAPN) platform that can repetitively display antigenic epitopes. Researchers used this platform to display a tandem repeat of the B cell immunodominant repeat epitope (DPPPPNPN)(2)D of the malaria parasite Plasmodium berghei circumsporozoite (CS) protein. Administered in saline, without the need for a heterologous adjuvant, the SAPN construct P4c-Mal conferred a long-lived, protective immune response to mice with a broad range of genetically distinct immune backgrounds including the H-2(b), H-2(d), and H-2(k) alleles. Mice were protected against an initial challenge of parasites up to 6 mo after the last immunization or for up to 15 mo against a second challenge after an initial challenge of parasites had successfully been cleared (Kaba et al., 2009).
Related Vaccines(s)	P. berghei CS Protein Subunit Vaccine , P. berghei DNA vaccine CSP-3p28 , P. berghei DNA vaccine encoding PbCSP
References

CS from P. berghei str. ANKA